000			03083nam a22005535i 4500
001			978-88-470-0391-0
003			DE-He213
005			20161121230744.0
007			cr nn 008mamaa
008			100301s2007 it | s |||| 0|eng d
020			_a9788847003910 _9978-88-470-0391-0
024	7		_a10.1007/978-88-470-0391-0 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
245	1	0	_aNeurodegeneration in Multiple Sclerosis _h[electronic resource] / _cedited by Massimo Filippi, Marco Rovaris, Giancarlo Comi.
264		1	_aMilano : _bSpringer Milan, _c2007.
300			_aXI, 236 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aTopics in Neuroscience
505	0		_aBackground -- Neuropathological Advances in Multiple Sclerosis -- Neurophysiology -- MRI Techniques to Assess Neurodegeneration -- Atrophy -- T1 Black Holes and Gray Matter Damage -- Magnetization Transfer Imaging -- Perfusion MR I -- Diffusion-Weighted Imaging -- Proton MR Spectroscopy -- Functional MRI -- Evaluation of MRI Outcomes -- Validation of MRI Surrogates -- Defining Responders and Non-responders -- Predictive Models in Multimodal Imaging -- Lessons from Other Neurodegenerative Diseases -- Alzheimer’s Disease -- Other Neurodegenerative Conditions -- Incorporation of Other Biomarkers -- Designing MS Trials for Neurodegeneration -- Critical Review of Existing Trials -- Design for the Next Trials of Neurodegeneration.
520			_aIn multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is dramatically changing our understanding of how MS causes irreversible disability. Written by world-renowned scientists, the volume is indispensable for anybody working in this field.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aRadiology.
650		0	_aNeuroradiology.
650		0	_aNuclear medicine.
650		0	_aNeurology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aNeurosciences.
650	2	4	_aImaging / Radiology.
650	2	4	_aNeuroradiology.
650	2	4	_aNuclear Medicine.
700	1		_aFilippi, Massimo. _eeditor.
700	1		_aRovaris, Marco. _eeditor.
700	1		_aComi, Giancarlo. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9788847003903
830		0	_aTopics in Neuroscience
856	4	0	_uhttp://dx.doi.org/10.1007/978-88-470-0391-0
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503493 _d503493