000 03864nam a22005655i 4500
001 978-3-540-49548-2
003 DE-He213
005 20161121230742.0
007 cr nn 008mamaa
008 100301s2007 gw | s |||| 0|eng d
020 _a9783540495482
_9978-3-540-49548-2
024 7 _a10.1007/978-3-540-49548-2
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
245 1 0 _aTissue-Specific Estrogen Action
_h[electronic resource] :
_bNovel Mechanisms, Novel Ligands, Novel Therapies /
_cedited by K. S. Korach, T. Wintermantel.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2007.
300 _aXV, 181 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aErnst Schering Foundation Symposium Proceedings,
_x0947-6075 ;
_v2006/1
505 0 _aInterfering with the Dynamics of Estrogen Receptor-Regulated Transcription -- Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues -- Genetic Dissection of Estrogen Receptor Signaling In Vivo -- Of Mice and Men: The Many Guises of Estrogens -- Estradiol Action in Atherosclerosis and Reendothelialization -- Functional Effects and Molecular Mechanisms of Subtype-Selective ER? and ER? Agonists in the Cardiovascular System -- Pathogenesis and Therapy of Rheumatoid Arthritis -- The Role of ER? and ER? in theProstate: Insights from Genetic Models and Isoform-Selective Ligands -- Preclinical Characterization of Selective Estrogen Receptor ? Agonists: New Insights into Their Therapeutic Potential -- Exploiting Nongenomic Estrogen Receptor-Mediated Signaling for the Development of Pathway-Selective Estrogen Receptor Ligands.
520 _aNuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aMolecular biology.
650 0 _aPharmacology.
650 0 _aGynecology.
650 0 _aEndocrinology.
650 0 _aMedical biochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aEndocrinology.
650 2 4 _aGynecology.
650 2 4 _aMedical Biochemistry.
650 2 4 _aMolecular Medicine.
650 2 4 _aPharmacology/Toxicology.
700 1 _aKorach, K. S.
_eeditor.
700 1 _aWintermantel, T.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540495475
830 0 _aErnst Schering Foundation Symposium Proceedings,
_x0947-6075 ;
_v2006/1
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-49548-2
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c503447
_d503447