000 03344nam a22004455i 4500
001 978-3-540-33990-8
003 DE-He213
005 20161121230741.0
007 cr nn 008mamaa
008 100301s2007 gw | s |||| 0|eng d
020 _a9783540339908
_9978-3-540-33990-8
024 7 _a10.1007/978-3-540-33990-8
_2doi
050 4 _aR895-920
072 7 _aMMPH
_2bicssc
072 7 _aMMP
_2bicssc
072 7 _aMED008000
_2bisacsh
082 0 4 _a616.0757
_223
245 1 0 _aTechnetium-99m Pharmaceuticals
_h[electronic resource] :
_bPreparation and Quality Control in Nuclear Medicine /
_cedited by Ilse Zolle.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2007.
300 _aXX, 345 p. 66 illus., 1 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aI -- Drug Safety -- Technetium in Medicine -- Stannous Chloride in the Preparation of 99mTc Pharmaceuticals -- Quality Assurance of Radiopharmaceuticals -- Performance and Quality Control of the 99Mo/99mTc Generator -- Preparation of Technetium 99mTc Pharmaceuticals -- Lyophilization Technique for Preparing Radiopharmaceutical Kits -- Cellular Labeling with 99mTc Chelates: Relevance of In Vitro and In Vivo Viability Testing -- Quality Control Methods of 99mTc Pharmaceuticals -- Other Technetium Isotopes: 94mTc as a Potential Substitute in Positron Emission Tomography Investigations -- The Rules Governing Medicinal Products for Human Use in the European Union -- II -- Monographs of 99mTc Pharmaceuticals.
520 _aThis textbook gives an account of the accomplishments related to the development of 99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of 99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered. Section 1 contains basic principles and methods used for analysis. Special emphasis is given to the analytical methods verifying pharmaceutical quality. Section 2 contains monographs of 99mTc-radiopharmaceuticals used in nuclear medicine. Each monograph includes information on the chemistry, formulation, commercial products and trade names, factors affection in-vivo performance, clinical information on pharmacokinetics, as well as details concerning the clinical application and the radiation dose to patients. This book can serve for daily practice in nuclear medicine, serving as a reference source as well as a teaching tool.
650 0 _aMedicine.
650 0 _aRadiology.
650 0 _aNuclear medicine.
650 1 4 _aMedicine & Public Health.
650 2 4 _aImaging / Radiology.
650 2 4 _aNuclear Medicine.
700 1 _aZolle, Ilse.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540339892
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-33990-8
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c503416
_d503416