000			03562nam a22004695i 4500
001			978-3-540-30328-2
003			DE-He213
005			20161121230740.0
007			cr nn 008mamaa
008			100301s2007 gw | s |||| 0|eng d
020			_a9783540303282 _9978-3-540-30328-2
024	7		_a10.1007/3-540-30328-6 _2doi
050		4	_aRC86-88.9
072		7	_aMMKL _2bicssc
072		7	_aMED015000 _2bisacsh
082	0	4	_a616.028 _223
245	1	0	_aMechanisms of Sepsis-Induced Organ Dysfunction and Recovery _h[electronic resource] / _cedited by Edward Abraham, Mervyn Singer.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2007.
300			_aXV, 453 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aUpdate in Intensive Care and Emergency Medicine, _x0933-6788 ; _v44
505	0		_aSetting the Scene -- Setting the Scene -- The Inflammatory Response -- Genetics and Severe Sepsis -- Cell Signaling Pathways of the Innate Immune System During Acute Inflammation -- Early-Onset Pro-inflammatory Cytokines -- The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine -- Nitric Oxide -- Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury -- Heat Shock Proteins in Inflammation -- Fibrosis in the Acute Respiratory Distress Syndrome -- Resolution of Inflammation -- The Cellular Immune Respone -- Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction -- The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome -- The Role of the Macrophage -- The Role of the Endothelium -- Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function -- Mechanisms and Pathways of Dysfunction -- Macrocirculatory Disturbances -- The Microcirculation Is a Vulnerable Organ in Sepsis -- The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body -- Coagulation in Sepsis -- The Role of Insulin and Blood Glucose Control -- Dysfunction of the Bioenergetic Pathway -- Metabolic Pathways -- Cell Death and Acute Lung Injury -- Mechanisms of Immunodepression after Central Nervous System Injury -- Organ-specific Mechanisms of Dysfunction -- Pulmonary Dysfunction -- The Gut -- Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1 -- Sepsis-induced Acute Renal Failure and Recovery -- Sepsis-Induced Brain Dysfunction -- Myocardial Depression in Sepsis and Septic Shock -- Skeletal Muscle.
520			_aThere have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
650		0	_aMedicine.
650		0	_aEmergency medicine.
650		0	_aCritical care medicine.
650	1	4	_aMedicine & Public Health.
650	2	4	_aIntensive / Critical Care Medicine.
650	2	4	_aEmergency Medicine.
700	1		_aAbraham, Edward. _eeditor.
700	1		_aSinger, Mervyn. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540301578
830		0	_aUpdate in Intensive Care and Emergency Medicine, _x0933-6788 ; _v44
856	4	0	_uhttp://dx.doi.org/10.1007/3-540-30328-6
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503397 _d503397