000			03836nam a22005655i 4500
001			978-1-84628-701-5
003			DE-He213
005			20161121230739.0
007			cr nn 008mamaa
008			100301s2007 xxk| s |||| 0|eng d
020			_a9781846287015 _9978-1-84628-701-5
024	7		_a10.1007/978-1-84628-701-5 _2doi
050		4	_aRC927-927.5
072		7	_aMJM _2bicssc
072		7	_aMED083000 _2bisacsh
082	0	4	_a616.723 _223
245	1	0	_aBone and Osteoarthritis _h[electronic resource] / _cedited by Felix Bronner, Mary C. Farach-Carson.
264		1	_aLondon : _bSpringer London, _c2007.
300			_aXIV, 218 p. 44 illus., 25 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aTopics in Bone Biology ; _v4
505	0		_aThe Pathogenesis of Osteoarthritis -- The Role of Bone in the Development of Osteoarthritis -- Cytokines, Growth Factors, and Bone-Derived Factors in Cartilage -- The Synovium and Its Role in Osteoarthritis -- Cartilage Matrix Destruction -- Anabolic Mediators of Cartilage Healing -- Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface -- Genetic and Epigenetic Aspects of Osteoarthritis -- Animal Models -- Biomechanical Aspects: Joint Injury and Osteoarthritis -- Novel Osteoarthritis Therapeutics.
520			_aBone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis. Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury. Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology. This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aInternal medicine.
650		0	_aGeriatrics.
650		0	_aRheumatology.
650		0	_aOrthopedics.
650		0	_aPediatrics.
650	1	4	_aMedicine & Public Health.
650	2	4	_aRheumatology.
650	2	4	_aOrthopedics.
650	2	4	_aInternal Medicine.
650	2	4	_aPediatrics.
650	2	4	_aGeriatrics/Gerontology.
650	2	4	_aHuman Physiology.
700	1		_aBronner, Felix. _eeditor.
700	1		_aFarach-Carson, Mary C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781846285134
830		0	_aTopics in Bone Biology ; _v4
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-84628-701-5
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503369 _d503369