000			03695nam a22005415i 4500
001			978-1-84628-440-3
003			DE-He213
005			20161121230738.0
007			cr nn 008mamaa
008			100301s2007 xxk| s |||| 0|eng d
020			_a9781846284403 _9978-1-84628-440-3
024	7		_a10.1007/978-1-84628-440-3 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
245	1	0	_aAbeta Peptide and Alzheimer’s Disease _h[electronic resource] : _bCelebrating a Century of Research / _cedited by Colin J. Barrow, David H. Small.
264		1	_aLondon : _bSpringer London, _c2007.
300			_aXI, 298 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aA Brief Introduction to the History of the ?-Amyloid Protein (A?) of Alzheimer’s Disease -- The A?centric Pathway of Alzheimer’s Disease -- The Function of the Amyloid Precursor Protein Family -- The Involvement of A? in the Neuroinflammatory Response -- Amyloid ?-Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease -- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer’s Disease -- A? Variants and Their Impact on Amyloid Formation and Alzheimer’s Disease Progression -- Copper Coordination by ?-Amyloid and the Neuropathology of Alzheimer’s Disease -- Cholesterol and Alzheimer’s Disease -- Amyloid ?-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer’s Disease Pathology -- Physiologic and Neurotoxic Properties of A? Peptides -- Impact of ?-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- Glial Cells and A? Peptides in Alzheimer’s Disease Pathogenesis -- The Role of Presenilins in A?-Induced Cell Death in Alzheimer’s Disease -- Immunotherapeutic Approaches to Alzheimer’s Disease -- Mouse Models of Alzheimer’s Disease.
520			_aAbeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinson’s and Huntington’s. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aMolecular biology.
650		0	_aNeurosciences.
650		0	_aMedical biochemistry.
650		0	_aNeurology.
650		0	_aNeurosurgery.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aNeurosurgery.
650	2	4	_aMedical Biochemistry.
650	2	4	_aNeurosciences.
650	2	4	_aMolecular Medicine.
650	2	4	_aHuman Genetics.
700	1		_aBarrow, Colin J. _eeditor.
700	1		_aSmall, David H. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781852339616
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-84628-440-3
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503353 _d503353