000			04243nam a22004935i 4500
001			978-1-59745-453-7
003			DE-He213
005			20161121230737.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9781597454537 _9978-1-59745-453-7
024	7		_a10.1007/978-1-59745-453-7 _2doi
050		4	_aRC648-665.2
072		7	_aMJG _2bicssc
072		7	_aMED027000 _2bisacsh
082	0	4	_a616.4 _223
245	1	4	_aThe Leydig Cell in Health and Disease _h[electronic resource] / _cedited by Anita H. Payne, Matthew P. Hardy.
264		1	_aTotowa, NJ : _bHumana Press, _c2007.
300			_aXII, 476 p. 79 illus., 2 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Endocrinology
505	0		_aHistorical -- A History of Leydig Cell Research -- Cell Biology -- Structural and Histological Analysis of Leydig Cell Steroidogenic Function -- Fetal Leydig Cells -- Regulation of Leydig Cells During Pubertal Development -- The Human Leydig Cell -- Dynamics of Leydig Cell Regeneration After EDS -- Aging and the Decline of Androgen Production -- Steroidogenesis -- Regulation of Leydig Cell Cholesterol Metabolism -- The Role of StAR in Leydig Cell Steroidogenesis -- Steroidogenic Enzymes in Leydig Cells -- Development of Leydig Cell Steroidogenesis -- Peripheral Testosterone Metabolism -- Leydig Cell Aromatase -- The Role of Estrogen Sulfotransferase in Leydig Cells -- Endocrinology of Leydig Cells in Nonmammalian Vertebrates -- Regulation -- The Luteinizing Hormone Receptor -- Insights Into Leydig Cell Function From Mice With Genetically Modified Gonadotropin Action -- Growth Factors in Leydig Cell Function -- Insulin-Like Peptide 3 in Leydig Cells -- Neuronal Signaling Molecules and Leydig Cells -- Regulation of Leydig Cell Function as it Pertains to the Inflammatory Response -- Activins and Leydig Cell Development Differentiation, and Disease -- Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function -- Androgen Receptor in Leydig Cell Function and Development -- Physiology and Applied Aspects -- Fluid Exchange and Transport of Hydrophilic Factors in the Testis -- Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology -- Induction of Leydig Cell Tumors by Xenobiotics -- Environmental Factors That Disrupt Leydig Cell Steroidogenesis -- The Leydig Cell as a Target for Male Contraception -- Clinical Evaluation of Leydig Cell Function.
520			_aNearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The Leydig Cell in Health and Disease explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive. This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aEndocrinology.
650		0	_aCell biology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aEndocrinology.
650	2	4	_aCell Biology.
650	2	4	_aHuman Physiology.
700	1		_aPayne, Anita H. _eeditor.
700	1		_aHardy, Matthew P. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588297549
830		0	_aContemporary Endocrinology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-453-7
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503336 _d503336