000			04799nam a22005535i 4500
001			978-1-59745-221-2
003			DE-He213
005			20161121230736.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9781597452212 _9978-1-59745-221-2
024	7		_a10.1007/978-1-59745-221-2 _2doi
050		4	_aRM845-862.5
072		7	_aMJCL1 _2bicssc
072		7	_aMED080000 _2bisacsh
082	0	4	_a615.842 _223
245	1	0	_aApoptosis, Senescence, and Cancer _h[electronic resource] / _cedited by David A. Gewirtz, Shawn E. Holt, Steven Grant.
264		1	_aTotowa, NJ : _bHumana Press, _c2007.
300			_aXVII, 599 p. 69 illus., 5 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development
505	0		_aApoptosis and Alternative Modes of Cell Death -- The Intrinsic Pathway of Apoptosis -- The Extrinsic Pathway of Apoptosis -- Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival -- Mitotic Catastrophe -- Autophagy and Autophagic Cell Death -- Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis -- Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis -- Structure and Function of the Telomere -- Overview of Senescence -- Contributions of Telomerase to Tumorigenesis -- The Role of Telomeres in Genomic Instability -- DNA Damage Response, Signaling Pathways, and Tumorigenesis -- Overview of the DNA Damage Checkpoint -- Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer -- Interplay Between ?H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response -- DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy -- Resistance and Sensitization -- Resistance/Signaling Pathways -- Ceramide and Multidrug Resistance -- Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling -- The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy -- Established Cancer Therapies -- Antimetabolites -- Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes -- Perturbations of Cellular Functions by Topoisomerase II Inhibitors -- The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs -- Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents -- Tyrosine Kinase Inhibitors -- Recent and Developing Cancer Therapies -- Monoclonal Antibodies in Lymphomas -- Role of Apoptosis in Anti-Angiogenic Cancer Therapies -- Photodynamic Therapy-Induced Apoptosis -- Modulation of TRAIL Signaling for Cancer Therapy.
520			_aApoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aPharmacology.
650		0	_aNuclear medicine.
650		0	_aRadiotherapy.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aRadiotherapy.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aNuclear Medicine.
650	2	4	_aPharmacology/Toxicology.
700	1		_aGewirtz, David A. _eeditor.
700	1		_aHolt, Shawn E. _eeditor.
700	1		_aGrant, Steven. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588295279
830		0	_aCancer Drug Discovery and Development
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-221-2
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503305 _d503305