000			04531nam a22005295i 4500
001			978-1-4020-6486-9
003			DE-He213
005			20161121230735.0
007			cr nn 008mamaa
008			100301s2007 ne | s |||| 0|eng d
020			_a9781402064869 _9978-1-4020-6486-9
024	7		_a10.1007/978-1-4020-6486-9 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
245	1	0	_aCreatine and Creatine Kinase in Health and Disease _h[electronic resource] / _cedited by Gajja S. Salomons, Markus Wyss.
264		1	_aDordrecht : _bSpringer Netherlands, _c2007.
300			_aXVIII, 354 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSubcellular Biochemistry, _x0306-0225 ; _v46
505	0		_a– Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease -- Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Membrane Transport -- The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches -- Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain -- A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis -- Functional Insights into the Creatine Transporter -- In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes -- Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment and Pathophysiology -- Pre-Symptomatic Treatment of Creatine Biosynthesis Defects -- Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders -- The Neuroprotective Role of Creatine -- Ergogenic Effects of Creatine in Sports and Rehabilitation -- Pharmacokinetics of Creatine -- Safety of Creatine Supplementation -- Creatine – its Chemical Synthesis, Chemistry, and Legal Status -- Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?.
520			_aAlthough creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aMedical biochemistry.
650		0	_aNeurology.
650		0	_aMedical research.
650		0	_aQuality of life.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aMedical Biochemistry.
650	2	4	_aHuman Genetics.
650	2	4	_aQuality of Life Research.
700	1		_aSalomons, Gajja S. _eeditor.
700	1		_aWyss, Markus. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402064852
830		0	_aSubcellular Biochemistry, _x0306-0225 ; _v46
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-6486-9
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503282 _d503282