000			03140nam a22004935i 4500
001			978-0-387-72204-7
003			DE-He213
005			20161121230735.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387722047 _9978-0-387-72204-7
024	7		_a10.1007/978-0-387-72204-7 _2doi
050		4	_aRC648-665.2
072		7	_aMJG _2bicssc
072		7	_aMED027000 _2bisacsh
082	0	4	_a616.4 _223
100	1		_aSaltiel, Alan R. _eauthor.
245	1	0	_aMechanisms of Insulin Action _h[electronic resource] : _bMedical Intelligence Unit / _cby Alan R. Saltiel, Jeffrey E. Pessin.
264		1	_aNew York, NY : _bSpringer New York, _c2007.
300			_aXI, 214 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aInsulin and IGF-I Receptor Structure and Binding Mechanism -- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events -- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis -- Control of Protein Synthesis by Insulin -- Hepatic Regulation of Fuel Metabolism -- Insulin Action Gene Regulation -- Insulin Action in the Islet ?-Cell -- Central Regulation of Insulin Sensitivity -- Transgenic Models of Impaired Insulin Signaling -- Insulin Resistance.
520			_aMore than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
650		0	_aMedicine.
650		0	_aCardiology.
650		0	_aDiabetes.
650		0	_aEndocrinology.
650		0	_aCell biology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aEndocrinology.
650	2	4	_aCell Biology.
650	2	4	_aDiabetes.
650	2	4	_aCardiology.
700	1		_aPessin, Jeffrey E. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387722030
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-72204-7
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503268 _d503268