000			04431nam a22004815i 4500
001			978-0-387-69219-7
003			DE-He213
005			20161121230734.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387692197 _9978-0-387-69219-7
024	7		_a10.1007/978-0-387-69219-7 _2doi
050		4	_aRC254-282
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a616.994 _223
245	1	0	_aCancer Metastasis And The Lymphovascular System: Basis For Rational Therapy _h[electronic resource] / _cedited by Stanley P. L. Leong.
264		1	_aBoston, MA : _bSpringer US, _c2007.
300			_aXVII, 309 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Treatment and Research, _x0927-3042 ; _v135
505	0		_aLandmarks and Advances in Translational Lymphology -- Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis -- Lymphatic Origin from Embryonic Stem Cells -- Lymphatic Markers, Tumour Lymphangiogenesis and Lymph Node Metastasis -- Anatomy of the Human Lymphatic System -- SPECT–CT Fusion Imaging Radionuclide Lymphoscintigraphy: Potential for Limb Lymphedema Assessment and Sentinel Node Detection In Breast Cancer -- Sentinel Node Identification using Radionuclides in Melanoma and Breast Cancer -- Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy -- Mechanisms of Metastasis: Seed and Soil -- Preclinical Models of Regional Lymph Node Tumor Metastasis -- A New Breast Cancer Model for Lymphatic Metastasis -- Lymph Node Micrometastases in Lung Cancer -- Effects of Chemokines on Tumor Metastasis -- Regional Lymph Node Metastases, a Singular Manifestation of the Process of Clinical Metastases in Cancer: Contemporary Animal Research And Clinical Reports Suggest Unifying Concepts -- Patterns of Metastatsis in Head and Neck Cancer -- Patterns of Metastasis in Human Solid Cancers -- Significance of Regional Draining Lymph Nodes in the Development of Tumor Immunity: Implications for Cancer Immunotherapy -- Targeting Small Molecules in Cancer -- Update on the Role of EGFR Inhibitors in Cancer Therapeutics -- New Promises in the Adjuvant, and Palliative Treatment of Melanoma -- Future Perspectives and Unanswered Questions on Cancer Metastasis and the Lymphovascular System.
520			_aSentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory. Series editor's comments: "Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process." Steven T. Rosen, MD Series Editor.
650		0	_aMedicine.
650		0	_aInternal medicine.
650		0	_aHematology.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aOncology.
650	2	4	_aHematology.
650	2	4	_aInternal Medicine.
700	1		_aLeong, Stanley P. L. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387692180
830		0	_aCancer Treatment and Research, _x0927-3042 ; _v135
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-69219-7
912			_aZDB-2-SME
950			_aMedicine (Springer-11650)
999			_c503251 _d503251