000 03858nam a22004455i 4500
001 978-0-387-31416-7
003 DE-He213
005 20161121230732.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 _a9780387314167
_9978-0-387-31416-7
024 7 _a10.1007/978-0-387-31416-7
_2doi
050 4 _aRC648-665.2
072 7 _aMJG
_2bicssc
072 7 _aMED027000
_2bisacsh
082 0 4 _a616.4
_223
245 1 0 _aLeptin
_h[electronic resource] /
_cedited by V. Daniel Castracane, Michael C. Henson.
264 1 _aBoston, MA :
_bSpringer US,
_c2007.
300 _aXIV, 372 p. 31 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEndocrine Updates,
_x1566-0729 ;
_v25
505 0 _aThe Obese (ob/ob) Mouse and the Discovery of Leptin -- Leptin Receptors -- Leptin and Obesity -- Leptin and Neuroendocrinology -- Leptin-Insulin Interrelationships -- Leptin and Other Endocrine Systems -- Leptin and Immune Function, Inflammation and Angiognenesis -- Leptin and Bone Central control of bone metabolism by leptin -- Roles and Regulation of Leptin in Reproduction -- Leptin and Cardiovascular Disease -- Leptin and Cancer -- Lipodystrophy: The experiment of nature to study leptin -- Pulsatile and Diurnal Leptin Rhythms -- Leptin in Farm Animals -- Genetic Disorders Involving Leptin and the Leptin Receptor -- Immunoassays for Leptin and Leptin Receptors -- Clinical Applications of Leptin.
520 _aThe discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology. A general interest in leptin has rapidly produced inroads into unexpected areas of physiology that may eventually elucidate the varied relationships of adiposity to human health and disease. These developments have been paralleled by a rigorous investigation as a product of pharmaceutical interest. The broad range of physiology and the clinical situations in which leptin is now implicated is reviewed for the first time in the present volume. ***Series Editor's comments**** This volume integrates cutting edge basic and clinical information encompassing the expression of leptin and leptin receptors, pathophysiology and clinical role of leptin- a new neuroendocrine hormone with pleiotropic roles in appetite regulation, metabolic, inflammatory, neoplastic, cardiovascular and reproductive functions. This single volume encyclopedic coverage is indispensable to students, postdoctoral trainees, fellows, scientists and practitioners interested in neuroendocrine peptide control of multiple cellular functions. Shlomo Melmed, M.D. Series Editor Endocrine Updates .
650 0 _aMedicine.
650 0 _aEndocrinology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aEndocrinology.
700 1 _aCastracane, V. Daniel.
_eeditor.
700 1 _aHenson, Michael C.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387314150
830 0 _aEndocrine Updates,
_x1566-0729 ;
_v25
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-31416-7
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c503203
_d503203