000 03230nam a22004335i 4500
001 978-3-7643-7378-8
003 DE-He213
005 20161121230709.0
007 cr nn 008mamaa
008 100301s2006 sz | s |||| 0|eng d
020 _a9783764373788
_9978-3-7643-7378-8
024 7 _a10.1007/3-7643-7378-4
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aCancer: Cell Structures, Carcinogens and Genomic Instability
_h[electronic resource].
264 1 _aBasel :
_bBirkhäuser Basel,
_c2006.
300 _aXI, 376 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aExperientia Supplementum ;
_v96
505 0 _aCancer morphology, carcinogenesis and genetic instability: a background -- Abnormalities of chromatin in tumor cells -- Aneuploidy, stem cells and cancer -- The mode of action of organic carcinogens on cellular structures -- Metal ions and carcinogenesis -- Actions of ultraviolet light on cellular structures -- Actions of radiation on living cells in the “post-bystander” era -- Viral carcinogenesis and genomic instability -- Abnormalities of cell structures in tumors: apoptosis in tumors -- Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications -- Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview -- Effects of ionizing radiation on cellular structures, induced instability and carcinogenesis -- Genetic instability in human tumors -- Molecular mechanisms of human carcinogenesis -- Mechanisms of abnormal gene expression in tumor cells.
520 _aTumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.
650 0 _aMedicine.
650 0 _aCancer research.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783764371562
830 0 _aExperientia Supplementum ;
_v96
856 4 0 _uhttp://dx.doi.org/10.1007/3-7643-7378-4
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502623
_d502623