000			03284nam a22005535i 4500
001			978-3-7643-7338-2
003			DE-He213
005			20161121230709.0
007			cr nn 008mamaa
008			100301s2005 sz | s |||| 0|eng d
020			_a9783764373382 _9978-3-7643-7338-2
024	7		_a10.1007/b137619 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
245	1	0	_aSt. John's Wort and its Active Principles in Depression and Anxiety _h[electronic resource] / _cedited by Walter E. Müller.
264		1	_aBasel : _bBirkhäuser Basel, _c2005.
300			_aVIII, 188 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMilestones in Drug Therapy MDT
505	0		_aand historical overview -- Phytochemistry -- St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies -- Effects on transmitter uptake and their cellular and molecular basis -- Modulation of neurotransmitter release and metabolism -- Efficacy in behavioural models of antidepressant activity -- Comparative preclinical antidepressant activity of isolated constituents -- Hyperforin and efficacy in animal models for anxiety and cognition -- Pharmacokinetics and biopharmaceuticals -- Clinical efficacy in depression -- Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression -- Side effects and drug interactions -- Endocrinology of St. John’s Wort extract.
520			_aHypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aPharmacology.
650		0	_aNeurology.
650		0	_aPsychiatry.
650		0	_aPsychotherapy.
650		0	_aPlant biochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aNeurosciences.
650	2	4	_aNeurology.
650	2	4	_aPsychiatry.
650	2	4	_aPsychotherapy.
650	2	4	_aPlant Biochemistry.
700	1		_aMüller, Walter E. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783764361600
830		0	_aMilestones in Drug Therapy MDT
856	4	0	_uhttp://dx.doi.org/10.1007/b137619
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502621 _d502621