000 | 03295nam a22004335i 4500 | ||
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001 | 978-3-540-33397-5 | ||
003 | DE-He213 | ||
005 | 20161121230708.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2006 gw | s |||| 0|eng d | ||
020 |
_a9783540333975 _9978-3-540-33397-5 |
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024 | 7 |
_a10.1007/978-3-540-33397-5 _2doi |
|
050 | 4 | _aQR46 | |
072 | 7 |
_aMMFM _2bicssc |
|
072 | 7 |
_aMED052000 _2bisacsh |
|
082 | 0 | 4 |
_a616.9041 _223 |
245 | 1 | 0 |
_aChemokines and Viral Infection _h[electronic resource] / _cedited by Thomas E. Lane. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2006. |
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300 |
_aXI, 160 p. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v303 |
|
505 | 0 | _aFunctional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System -- Cytokine and Chemokine Networks: Pathways to Antiviral Defense -- Herpes Simplex Virus and the Chemokines That Mediate the Inflammation -- Influence of Proinflammatory Cytokines and Chemokines on the Neuropathogenesis of Oncornavirus and Immunosuppressive Lentivirus Infections -- HIV-1 Coreceptors and Their Inhibitors -- A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors. | |
520 | _aThis edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aMedical microbiology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aMedical Microbiology. |
700 | 1 |
_aLane, Thomas E. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783540292074 |
830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v303 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-540-33397-5 |
912 | _aZDB-2-SBL | ||
950 | _aBiomedical and Life Sciences (Springer-11642) | ||
999 |
_c502590 _d502590 |