000 03295nam a22004335i 4500
001 978-3-540-33397-5
003 DE-He213
005 20161121230708.0
007 cr nn 008mamaa
008 100301s2006 gw | s |||| 0|eng d
020 _a9783540333975
_9978-3-540-33397-5
024 7 _a10.1007/978-3-540-33397-5
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
245 1 0 _aChemokines and Viral Infection
_h[electronic resource] /
_cedited by Thomas E. Lane.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _aXI, 160 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v303
505 0 _aFunctional Diversity of Chemokines and Chemokine Receptors in Response to Viral Infection of the Central Nervous System -- Cytokine and Chemokine Networks: Pathways to Antiviral Defense -- Herpes Simplex Virus and the Chemokines That Mediate the Inflammation -- Influence of Proinflammatory Cytokines and Chemokines on the Neuropathogenesis of Oncornavirus and Immunosuppressive Lentivirus Infections -- HIV-1 Coreceptors and Their Inhibitors -- A Viral Conspiracy: Hijacking the Chemokine System Through Virally Encoded Pirated Chemokine Receptors.
520 _aThis edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
650 0 _aMedicine.
650 0 _aMedical microbiology.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
700 1 _aLane, Thomas E.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540292074
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v303
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-540-33397-5
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502590
_d502590