000 03273nam a22004575i 4500
001 978-3-540-32952-7
003 DE-He213
005 20161121230708.0
007 cr nn 008mamaa
008 100301s2006 gw | s |||| 0|eng d
020 _a9783540329527
_9978-3-540-32952-7
024 7 _a10.1007/3-540-32952-8
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
245 1 4 _aThe Myc/Max/Mad Transcription Factor Network
_h[electronic resource] /
_cedited by R. N. Eisenman.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _aVII, 282 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v302
505 0 _aMaking Myc -- Transcriptional Activation by the Myc Oncoprotein -- Mechanisms of Transcriptional Repression by Myc -- The Mad Side of the Max Network: Antagonizing the Function of Myc and More -- Structural Aspects of Interactions Within the Myc/Max/Mad Network -- Myc Target Transcriptomes -- c-Myc, Genome Instability, and Tumorigenesis: The Devil Is in the Details -- Lessons Learned from Myc/Max/Mad Knockout Mice -- Myc/Max/Mad in Invertebrates: The Evolution of the Max Network -- The Mlx Network: Evidence for a Parallel Max-Like Transcriptional Network That Regulates Energy Metabolism.
520 _aIntense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aMedical microbiology.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aHuman Genetics.
700 1 _aEisenman, R. N.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540239680
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v302
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-32952-8
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502585
_d502585