000 | 03783nam a22004215i 4500 | ||
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001 | 978-3-540-32948-0 | ||
003 | DE-He213 | ||
005 | 20161121230708.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2006 gw | s |||| 0|eng d | ||
020 |
_a9783540329480 _9978-3-540-32948-0 |
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024 | 7 |
_a10.1007/978-3-540-32948-0 _2doi |
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050 | 4 | _aR-RZ | |
072 | 7 |
_aMBGR _2bicssc |
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072 | 7 |
_aMED000000 _2bisacsh |
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082 | 0 | 4 |
_a610 _223 |
245 | 1 | 0 |
_aInnervation of the Mammalian Esophagus _h[electronic resource] / _cedited by W.L. Neuhuber. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2006. |
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300 |
_aX, 76 p. 14 illus. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aAdvances in Anatomy, Embryology and Cell Biology, _x0301-5556 ; _v185 |
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505 | 0 | _aIntroduction -- Muscle layers of the esophagus -- Materials and Methods. Anterograde WGA-HRP tracing from nodose ganglion. Anterograde DiI tracing from thoracic dorsal root ganglia -- Extrinsic innervation. Vagal innervation -- Spinal innervation. Innervation of esophageal sphincters. Swallowing central pattern generator. Cortical representation of the esophagus in human -- Intrinsic innervation. General organization. Enteric coinnervation -- Functional considerations. General remarks. Cooperation between extrinsic and intrinsic systems -- Concluding remarks -- Summary -- References -- Subject Index. | |
520 | _aUnderstanding the innervation of the esophagus is a prerequisite for successful treatment of a variety of disorders, e.g., dysphagia, achalasia, gastroesophageal reflux disease (GERD) and non-cardiac chest pain. Although, at first glance, functions of the esophagus are relatively simple, their neuronal control is considerably complex. Vagal motor neurons of the nucleus ambiguus and preganglionic neurons of the dorsal motor nucleus innervate striated and smooth muscle, respectively. Myenteric neurons represent the interface between the dorsal motor nucleus and smooth muscle but are also involved in striated muscle innervation. Intraganglionic laminar endings (IGLEs) represent mechanosensory vagal afferent terminals. They also establish intricate connections with enteric neurons. Afferent information is implemented by the swallowing central pattern generator in the brainstem, which generates and coordinates deglutitive activity in both striated and smooth esophageal muscle and orchestrates esophageal sphincters as well as gastric adaptive relaxation. Disturbed excitation/inhibition balance in the lower esophageal sphincter results in motility disorders, e.g., achalasia and gastroesophageal reflux disease. Loss of mechanosensory afferents disrupts adaptation of deglutitive motor programs to bolus variables, eventually leading to megaesophagus. Both spinal and vagal afferents appear to contribute to painful sensations, e.g., non-cardiac chest pain. Extrinsic and intrinsic neurons may be involved in intramural reflexes using acetylcholine, nitric oxide, substance P, CGRP and glutamate as main transmitters. In addition, other molecules, e.g., ATP, GABA and probably also inflammatory cytokines may modulate these neuronal functions. | ||
650 | 0 | _aMedicine. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aBiomedicine general. |
700 | 1 |
_aNeuhuber, W.L. _eeditor. |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783540292050 |
830 | 0 |
_aAdvances in Anatomy, Embryology and Cell Biology, _x0301-5556 ; _v185 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-540-32948-0 |
912 | _aZDB-2-SBL | ||
950 | _aBiomedical and Life Sciences (Springer-11642) | ||
999 |
_c502584 _d502584 |