000 04521nam a22004935i 4500
001 978-3-540-31265-9
003 DE-He213
005 20161121230706.0
007 cr nn 008mamaa
008 100301s2006 gw | s |||| 0|eng d
020 _a9783540312659
_9978-3-540-31265-9
024 7 _a10.1007/3-540-31265-X
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 0 _aStem Cells
_h[electronic resource] /
_cedited by Anna M. Wobus, Kenneth R. Boheler.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _aXII, 414 p. 53 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v174
505 0 _aFactors Involved in Self-Renewal and Pluripotency of Embryonic Stem Cells -- Embryonic Stem Cell-Derived Embryoid Bodies: An In Vitro Model of Eutherian Pregastrulation Development and Early Gastrulation -- Embryonic Stem Cells: A Novel Tool for the Study of Antiangiogenesis and Tumor-Induced Angiogenesis -- Cardiac Repair by Embryonic Stem-Derived Cells -- Cardiomyocytes from Human Embryonic Stem Cells -- Autocrine and Intracrine Signaling for Cardiogenesis in Embryonic Stem Cells: A Clue for the Development of Novel Differentiating Agents -- Therapeutic Potential of Stem Cells in Diabetes -- The Stem Cell Continuum: A New Model of Stem Cell Regulation -- Markers of Adult Tissue-Based Stem Cells -- Designer Cytokines for Human Haematopoietic Progenitor Cell Expansion: Impact for Tissue Regeneration -- Mesenchymal Stem Cells: Isolation, In Vitro Expansion and Characterization -- Neovascularization and Cardiac Repair by Bone Marrow-Derived Stem Cells -- The Potential Use of Myogenic Stem Cells in Regenerative Medicine -- Neural Stem Cells: On Where They Hide, in Which Disguise, and How We May Lure Them Out -- Cell Transplantation for Patients with Parkinson’s Disease -- Postmodern Biology: (Adult) (Stem) Cells Are Plastic, Stochastic, Complex, and Uncertain.
520 _aSigni?cant advances in stem cell research and their potentials for therap- tic applications have attracted the attention of the scienti?c community and captured the imagination of society as a whole. Not so long ago, the study of most stem cells, other than those that regenerated the haematopoietic system, was rather obscure and limited to a relatively small number of researchers and laboratories. The uproar over stem cells really began in 1998 with the s- cessful derivation of pluripotent human embryonic stem (ES) cells by James Thomson and co-workers. This breakthrough and the subsequent generation of specialized human cells in vitro led to a paradigm shift within the sci- ti?c community, which transformed this specialized endeavour from a topic of scienti?c interest to a line of investigation with the potential to generate cells - pable of treating serious ailments, including diabetes, cardiovascular diseases and neurodegenerative disorders. Thus the dawn of regenerative medicine has spawned from the somewhat esoteric study of stem cells. Since 1998, extensive research endeavours have been devoted to the study of both embryonic and adult stem cells. Early reports suggested that adult stem cells had a higher plasticity than previously believed, perhaps even comparable with that demonstrated by embryonic stem cells, but several observations of the so-called transdifferentiation capacity and plasticity of adult stem cells have not been repeated. These reports, however, encouraged on-going debates about the capacity of adult versus embryonic stem cells and their potential use in regenerative medicine.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aNeurosciences.
650 0 _aPharmacology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aHuman Genetics.
650 2 4 _aNeurosciences.
700 1 _aWobus, Anna M.
_eeditor.
700 1 _aBoheler, Kenneth R.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540261339
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v174
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-31265-X
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502555
_d502555