000 03009nam a22004455i 4500
001 978-3-540-29933-2
003 DE-He213
005 20161121230706.0
007 cr nn 008mamaa
008 100301s2005 gw | s |||| 0|eng d
020 _a9783540299332
_9978-3-540-29933-2
024 7 _a10.1007/3-540-29933-5
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aChronic Lymphocytic Leukemia
_h[electronic resource].
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aX, 190 p. 40 illus., 5 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v294
505 0 _aB Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage -- Gene Expression Patterns in Human and Mouse B Cell Development -- New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia -- Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models -- What Do Somatic Hypermutation and Class Switch Recombination Teach Us About Chronic Lymphocytic Leukaemia Pathogenesis? -- Chronic Lymphocytic Leukaemia: A Review of the Immuno-architecture -- Clinical and Laboratory Parameters That Define Clinically Relevant B-CLL Subgroups -- Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements -- Genotypic Prognostic Markers -- Chronic Lymphocytic Leukaemia: Clinical Translations of Biological Features.
520 _aChronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHematology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aHematology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540252795
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v294
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-29933-5
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502536
_d502536