000 02937nam a22004575i 4500
001 978-3-540-29802-1
003 DE-He213
005 20161121230705.0
007 cr nn 008mamaa
008 100301s2006 gw | s |||| 0|eng d
020 _a9783540298021
_9978-3-540-29802-1
024 7 _a10.1007/3-540-29802-9
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
245 1 0 _aHepatitis Delta Virus
_h[electronic resource] /
_cedited by John L. Casey.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _aXII, 228 p. 18 illus., 1 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v307
505 0 _aStructure and Replication of Hepatitis Delta Virus RNA -- HDV RNA Replication: Ancient Relic or Primer? -- HDV Ribozymes -- RNA Editing in Hepatitis Delta Virus -- Post-translational Modification of Delta Antigen of Hepatitis D Virus -- The Role of the HBV Envelope Proteins in the HDV Replication Cycle -- Prenylation of HDAg and Antiviral Drug Development -- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades? -- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection -- Immunology of HDV Infection -- The Woodchuck Model of HDV Infection.
520 _aSince its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
650 0 _aMedicine.
650 0 _aMedical microbiology.
650 0 _aVirology.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aMedical Microbiology.
700 1 _aCasey, John L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540298014
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v307
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-29802-9
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502531
_d502531