000 | 02937nam a22004575i 4500 | ||
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001 | 978-3-540-29802-1 | ||
003 | DE-He213 | ||
005 | 20161121230705.0 | ||
007 | cr nn 008mamaa | ||
008 | 100301s2006 gw | s |||| 0|eng d | ||
020 |
_a9783540298021 _9978-3-540-29802-1 |
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024 | 7 |
_a10.1007/3-540-29802-9 _2doi |
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050 | 4 | _aQR355-502 | |
072 | 7 |
_aMMFM _2bicssc |
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072 | 7 |
_aMED052000 _2bisacsh |
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082 | 0 | 4 |
_a616.9101 _223 |
245 | 1 | 0 |
_aHepatitis Delta Virus _h[electronic resource] / _cedited by John L. Casey. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2006. |
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300 |
_aXII, 228 p. 18 illus., 1 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v307 |
|
505 | 0 | _aStructure and Replication of Hepatitis Delta Virus RNA -- HDV RNA Replication: Ancient Relic or Primer? -- HDV Ribozymes -- RNA Editing in Hepatitis Delta Virus -- Post-translational Modification of Delta Antigen of Hepatitis D Virus -- The Role of the HBV Envelope Proteins in the HDV Replication Cycle -- Prenylation of HDAg and Antiviral Drug Development -- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades? -- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection -- Immunology of HDV Infection -- The Woodchuck Model of HDV Infection. | |
520 | _aSince its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aMedical microbiology. | |
650 | 0 | _aVirology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aVirology. |
650 | 2 | 4 | _aMedical Microbiology. |
700 | 1 |
_aCasey, John L. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783540298014 |
830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v307 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/3-540-29802-9 |
912 | _aZDB-2-SBL | ||
950 | _aBiomedical and Life Sciences (Springer-11642) | ||
999 |
_c502531 _d502531 |