| 000 | 03322nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-3-540-28902-9 | ||
| 003 | DE-He213 | ||
| 005 | 20161121230705.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2005 gw | s |||| 0|eng d | ||
| 020 |
_a9783540289029 _9978-3-540-28902-9 |
||
| 024 | 7 |
_a10.1007/3-540-28902-X _2doi |
|
| 050 | 4 | _aQP34-38 | |
| 072 | 7 |
_aMFG _2bicssc |
|
| 072 | 7 |
_aMED075000 _2bisacsh |
|
| 082 | 0 | 4 |
_a612 _223 |
| 245 | 1 | 0 |
_aDeciphering Growth _h[electronic resource] / _cedited by Jean-Claude Carel, Paul A. Kelly, Yves Christen. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2005. |
|
| 300 |
_aXIII, 155 p. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 | _aResearch and Perspectives in Endocrine Interactions | |
| 505 | 0 | _aEvolutionary Trends in Body Size -- Sexual Dimorphism in the Growth of Homo sapiens: Facts, Inferences and Speculation -- Genetic Control of Size at Birth -- The GH/IGF-1 Axis: Insights from Animal Models -- Downstream Mechanisms of Growth Hormone Action -- Growth Hormone Receptor Signaling and Differential Actions in Target Tissues Compared to IGF-I -- IGF-I and Brain Growth: Multifarious Effects on Developing Neural Cells and Mechanisms of Action -- IGF-I Deficiency: Lessons from Human Mutations -- Putting IGF-I Biology into a Clinical Perspective -- IGF Resistance: The Role of the Type 1 IGF Receptor -- The Importance of the National Cooperative Growth Study (NCGS) -- Why we are Treating Children with Growth Hormone: Lessons from the French Registry. | |
| 520 | _aGrowth is a complex process that is essential to life. Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. In mammals, the major factors involved in the regulation of body growth are known: insulin-like growth factors (IGF) are key regulators of somatic growth. Growth hormone (GH), secreted by the pituitary gland, directly regulates circulating levels of IGF-I, which is the major coordinator of spatio-temporal growth of the organism. In humans, growth involves a number of specific characteristics not found in other species. These include rapid intrauterine growth, deceleration just after birth, a mid-childhood growth spurt, a second deceleration before puberty, an adolescent growth spurt, and finally full statural growth, which is seen somewhat later. The combined knowledge concerning the endocrine and paracrine aspects of growth have led to the introduction of treatment regimens, most effective in GH-deficient children. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aHuman physiology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aHuman Physiology. |
| 700 | 1 |
_aCarel, Jean-Claude. _eeditor. |
|
| 700 | 1 |
_aKelly, Paul A. _eeditor. |
|
| 700 | 1 |
_aChristen, Yves. _eeditor. |
|
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783540261926 |
| 830 | 0 | _aResearch and Perspectives in Endocrine Interactions | |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/3-540-28902-X |
| 912 | _aZDB-2-SBL | ||
| 950 | _aBiomedical and Life Sciences (Springer-11642) | ||
| 999 |
_c502517 _d502517 |
||