000			03888nam a22004455i 4500
001			978-3-540-28007-1
003			DE-He213
005			20161121230704.0
007			cr nn 008mamaa
008			100301s2005 gw | s |||| 0|eng d
020			_a9783540280071 _9978-3-540-28007-1
024	7		_a10.1007/3-540-28007-3 _2doi
050		4	_aQR46
072		7	_aMMFM _2bicssc
072		7	_aMED052000 _2bisacsh
082	0	4	_a616.9041 _223
245	1	0	_aDislocation and Degradation of Proteins from the Endoplasmic Reticulum _h[electronic resource] / _cedited by Emmanuel Wiertz, Marjolein Kikkert.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2005.
300			_aXI, 174 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v300
505	0		_aThe Secretory Capacity of a Cell Depends on the Efficiency of Endoplasmic Reticulum-Associated Degradation -- Recognition and Delivery of ERAD Substrates to the Proteasome and Alternative Paths for Cell Survival -- CPY* and the Power of Yeast Genetics in the Elucidation of Quality Control and Associated Protein Degradation of the Endoplasmic Reticulum -- The Role of the Ubiquitination Machinery in Dislocation and Degradation of Endoplasmic Reticulum Proteins -- The Role of p97/Cdc48p in Endoplasmic Reticulum-Associated Degradation: From the Immune System to Yeast -- The Ins and Outs of Intracellular Peptides and Antigen Presentation by MHC Class I Molecules -- Entry of Protein Toxins into Mammalian Cells by Crossing the Endoplasmic Reticulum Membrane: Co-opting Basic Mechanisms of Endoplasmic Reticulum-Associated Degradation.
520			_aThe present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). This area is of immediate medical relevance and has blossomed, to no small extent, because of the study of molecules central to the function of the immune system [immunogl- ulins, T cell receptors, major histocompatibility complex (MHC)-encoded products]. Similarly, the clever strategies used by bacteria or viruses to gain a foothold in the host and ensure their continued survival have uncovered altogether new cell biological principles. It is therefore ?tting that a special volume be devoted to the interplay between pathways of protein degradation in the ER and a wide variety of pathogens. The concept of quality control emerged with the appreciation that, in the case of multimeric glycoproteins, any unpaired glycoprotein subunit had great dif?culties leaving its site of synthesis—the ER—and was destroyed instead. Free immunoglobulin heavy chains were probably the earliest documented example of this kind, and were long known to cause pathology when their accumulation went unchecked. Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made. The T cell receptor for antigen, long considered the paradigm of this mode of degradation, led the way in these early explorations.
650		0	_aMedicine.
650		0	_aMedical microbiology.
650	1	4	_aBiomedicine.
650	2	4	_aMedical Microbiology.
700	1		_aWiertz, Emmanuel. _eeditor.
700	1		_aKikkert, Marjolein. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540280064
830		0	_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v300
856	4	0	_uhttp://dx.doi.org/10.1007/3-540-28007-3
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502499 _d502499