000			03658nam a22004455i 4500
001			978-3-540-27832-0
003			DE-He213
005			20161121230704.0
007			cr nn 008mamaa
008			100301s2005 gw | s |||| 0|eng d
020			_a9783540278320 _9978-3-540-27832-0
024	7		_a10.1007/3-540-27832-X _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aMilz, Stefan. _eauthor.
245	1	0	_aMolecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue _h[electronic resource] / _cby Stefan Milz, Michael Benjamin, Reinhard Putz.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2005.
300			_aVI, 74 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Anatomy Embryology and Cell Biology, _x0301-5556 ; _v178
505	0		_aIntroduction: Preliminary remarks; Adaptation of connective and supportive tissues to their respective functions; Parameters of functional adaptation -- Study aim: Fundamental considerations; Structure of the present study; Questions -- Anatomical structures investigated: Extensor tendons of the toes in the region of the proximal interphalangeal joint (PIP); Extensor tendons of the hand in the region of the MCP joint; The transverse ligament of the atlas; The transverse ligament of the acetabulum; Tendon and trochlea of the superior oblique muscle -- Materials and methods: Materials; Methodology of the immunohistochemical investigation -- Results: Extensor tendons of the toes; Extensor tendons of the hand in the region of the MCP joint; The transverse ligament of the atlas -- Discussion: Discussion of the method; Discussion of the present study's structure; Discussion of results; Conclusions -- Summary -- Bibliography -- Subject Index.
520			_aThe present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated. In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods. The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue. The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage.
650		0	_aMedicine.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
700	1		_aBenjamin, Michael. _eauthor.
700	1		_aPutz, Reinhard. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540244745
830		0	_aAdvances in Anatomy Embryology and Cell Biology, _x0301-5556 ; _v178
856	4	0	_uhttp://dx.doi.org/10.1007/3-540-27832-X
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502497 _d502497