000 04970nam a22005655i 4500
001 978-3-540-27702-6
003 DE-He213
005 20161121230704.0
007 cr nn 008mamaa
008 100301s2005 gw | s |||| 0|eng d
020 _a9783540277026
_9978-3-540-27702-6
024 7 _a10.1007/3-540-27702-1
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aCD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
_h[electronic resource] /
_cedited by R.W. Compans, M.D. Cooper, T. Honjo, H. Koprowski, F. Melchers, M.B.A. Oldstone, S. Olsnes, M. Potter, P.K. Vogt, H. Wagner, Bruno Kyewski, Elisabeth Suri-Payer.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2005.
300 _aXII, 332 p. 18 illus., 12 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v293
505 0 _aOrigin and Generation -- Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides -- The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology -- Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection -- Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models -- Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets -- Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells -- Dendritic Cells: Key Cells for the Induction of Regulatory T Cells? -- Involvement of Disease Models -- Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression -- Regulatory T Cells in Experimental Colitis -- Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control -- Regulatory T Cells in Transplantation Tolerance -- CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation -- Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity -- Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.
520 _aThe vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.
650 0 _aMedicine.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
700 1 _aCompans, R.W.
_eeditor.
700 1 _aCooper, M.D.
_eeditor.
700 1 _aHonjo, T.
_eeditor.
700 1 _aKoprowski, H.
_eeditor.
700 1 _aMelchers, F.
_eeditor.
700 1 _aOldstone, M.B.A.
_eeditor.
700 1 _aOlsnes, S.
_eeditor.
700 1 _aPotter, M.
_eeditor.
700 1 _aVogt, P.K.
_eeditor.
700 1 _aWagner, H.
_eeditor.
700 1 _aKyewski, Bruno.
_eeditor.
700 1 _aSuri-Payer, Elisabeth.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540244448
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v293
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-27702-1
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502492
_d502492