000			03371nam a22004335i 4500
001			978-3-540-26765-2
003			DE-He213
005			20161121230703.0
007			cr nn 008mamaa
008			100301s2005 gw | s |||| 0|eng d
020			_a9783540267652 _9978-3-540-26765-2
024	7		_a10.1007/b138038 _2doi
050		4	_aQR355-502
072		7	_aMMFM _2bicssc
072		7	_aMED052000 _2bisacsh
082	0	4	_a616.9101 _223
245	1	0	_aCoronavirus Replication and Reverse Genetics _h[electronic resource] / _cedited by Luis Enjuanes.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2005.
300			_aXI, 257 p. 49 illus., 18 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v287
505	0		_aCoronavirus Genome Structure and Replication -- Coronavirus Transcription: A Perspective -- The Coronavirus Replicase -- Viral and Cellular Proteins Involved in Coronavirus Replication -- Coronavirus Reverse Genetics by Targeted RNA Recombination -- Coronavirus Reverse Genetics and Development of Vectors for Gene Expression -- Reverse Genetics of Coronaviruses Using Vaccinia Virus Vectors -- Development of Mouse Hepatitis Virus and SARS-CoV Infectious cDNA Constructs.
520			_aCoronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
650		0	_aMedicine.
650		0	_aVirology.
650	1	4	_aBiomedicine.
650	2	4	_aVirology.
700	1		_aEnjuanes, Luis. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540214946
830		0	_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v287
856	4	0	_uhttp://dx.doi.org/10.1007/b138038
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502466 _d502466