000			03840nam a22004455i 4500
001			978-1-59745-058-4
003			DE-He213
005			20161121230702.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9781597450584 _9978-1-59745-058-4
024	7		_a10.1007/978-1-59745-058-4 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aTransgenic and Knockout Models of Neuropsychiatric Disorders _h[electronic resource] / _cedited by Gene S. Fisch, Jonathan Flint.
264		1	_aTotowa, NJ : _bHumana Press, _c2006.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Clinical Neuroscience
505	0		_aand Overview -- Transgenic and Knockout Models of Psychiatric Disorders -- Transgenic Mouse Models and Human Psychiatric Disease -- Transgenic and Knockout Mouse Models -- If Only They Could Talk -- Transgenic and Knockout Models of Neurocognitive Dysfunction -- Spinocerebellar Ataxia Type 1 -- Mouse Models of Hereditary Mental Retardation -- How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders? -- Animal Models of Autism -- Transgenic and Knockout Models of Neuropsychiatric Dysfunction -- Genetic Mouse Models of Psychiatric Disorders -- Animal Models of Psychosis -- Animal Models of Anxiety -- Modeling Human Anxiety and Depression in Mutant Mice -- Mutant Mouse Models of Bipolar Disorder.
520			_aNeuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.
650		0	_aMedicine.
650		0	_aNeurosciences.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
700	1		_aFisch, Gene S. _eeditor.
700	1		_aFlint, Jonathan. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588295071
830		0	_aContemporary Clinical Neuroscience
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59745-058-4
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502447 _d502447