000			03384nam a22004335i 4500
001			978-1-59745-024-9
003			DE-He213
005			20161121230702.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9781597450249 _9978-1-59745-024-9
024	7		_a10.1385/1597450243 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aHistone Deacetylases _h[electronic resource] : _bTranscriptional Regulation and Other Cellular Functions / _cedited by Eric Verdin.
264		1	_aTotowa, NJ : _bHumana Press, _c2006.
300			_a352 p. 63 illus., 1 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development
505	0		_aClass I Histone Deacetylases -- Histone Deacetylase 1 -- Biochemistry of Multiprotein HDAC Complexes -- The Biology of HDAC3 -- The Biology of HDAC8, a Unique Class I Histone Deacetylase -- Class II Histone Deacetylases -- Regulation of Muscle Gene Expression by Histone Deacetylases -- The Class IIa Histone Deacetylases -- Histone Deacetylases in the Response to Misfolded Proteins -- Class III Histone Deacetylases -- Evolution of Sirtuins From Archaea to Vertebrates -- Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases -- The Enzymology of SIR2 Proteins -- The Class III Protein Deacetylases -- Histone Deacetylase Inhibitors -- HDAC Inhibitors -- Cell Cycle Targets of Histone Deacetylase Inhibitors -- HDAC Inhibitors.
520			_aThe recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.
650		0	_aMedicine.
650		0	_aCancer research.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
700	1		_aVerdin, Eric. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588294999
830		0	_aCancer Drug Discovery and Development
856	4	0	_uhttp://dx.doi.org/10.1385/1597450243
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502446 _d502446