000			03526nam a22004335i 4500
001			978-1-59259-930-1
003			DE-He213
005			20161121230702.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592599301 _9978-1-59259-930-1
024	7		_a10.1007/978-1-59259-930-1 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	0	_aComputational Genetics and Genomics _h[electronic resource] : _bTools for Understanding Disease / _cedited by Gary Peltz.
264		1	_aTotowa, NJ : _bHumana Press, _c2005.
300			_aX, 308 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aTheory and Technical Concept -- Computational Biology -- Statistical Theory in QTL Mapping -- Haplotype-Based Computational Genetic Analysis In Mice -- Haplotype Structure of the Mouse Genome -- SNP Discovery and Genotyping -- Selected Examples: Murine Models of Human Disease -- Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Models -- Murine Models of Osteoporosis -- Murine Models of Substance and Alcohol Dependence -- Murine Models of Alcoholism -- Selected Examples: The Genetic Basis for Human Disease -- HLA Polymorphism and Disease Susceptibility -- Asthma Genetics.
520			_aDespite ever-increasing investments in genetic research, the translation of genetic discoveries into new therapies has been a slow process. In Computational Genetics and Genomics: Tools for Understanding Disease, well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiological or pathological responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases. They also describe how genetic analysis of human populations has yielded information on the genetic basis for susceptibility to asthma and other inflammatory diseases. Authoritative and path-breaking, Computational Genetics and Genomics: Tools for Understanding Disease surveys and assesses both currently available and powerful new computational genetic mapping methods that can be used to quickly analyze genetic models of biomedically important traits. This information provides a basis for uncovering the genetic factors regulating human disease-related traits.
650		0	_aMedicine.
650		0	_aHuman genetics.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
700	1		_aPeltz, Gary. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588291875
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59259-930-1
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502437 _d502437