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001 978-1-59259-914-1
003 DE-He213
005 20161121230702.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9781592599141
_9978-1-59259-914-1
024 7 _a10.1385/1592599141
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
245 1 0 _aNeural Development and Stem Cells
_h[electronic resource] /
_cedited by Mahendra S. Rao.
250 _aSecond Edition.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2006.
300 _a468p. 84 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aContemporary Neuroscience
505 0 _aDefining Neural Stem Cells and Their Role in Normal Development of the Nervous System -- Neural Stem Cells in the Adult Brain -- Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny -- Multipotent Stem Cells in the Embryonic Nervous System -- Regulation of Neural Stem Cell Death -- Neuronal Progenitor Cells of the Mammalian Neonatal Anterior Subventricular Zone -- Glial Restricted Precursors -- PNS Precursor Cells in Development and Cancer -- Stem Cells of the Adult Olfactory Epithelium -- Retinal Stem Cells -- Transdifferentiation in the Nervous System -- Neural Progenitor Cells of the Adult Human Brain -- Embryonic Stem Cells and Neurogenesis -- Mobilization of Neural Precursors in the Adult Central Nervous System -- Neural Stem Cells and Transplant Therapy.
520 _aDeveloping the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).
650 0 _aMedicine.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
700 1 _aRao, Mahendra S.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781588294814
830 0 _aContemporary Neuroscience
856 4 0 _uhttp://dx.doi.org/10.1385/1592599141
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502433
_d502433