000			03642nam a22004335i 4500
001			978-1-59259-825-0
003			DE-He213
005			20161121230701.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592598250 _9978-1-59259-825-0
024	7		_a10.1007/978-1-59259-825-0 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
245	1	0	_aNeonatal Immunity _h[electronic resource] / _cedited by Constantin Bona.
264		1	_aTotowa, NJ : _bHumana Press, _c2005.
300			_aXII, 389 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Immunology
505	0		_aStructure and Function of the Immune System in Vertebrates -- Ontogeny and the Development of Cells Mediating Innate and Adaptive Immunity -- Phenotypic Characteristics of Neonatal B Cells -- Molecular Characteristics of the Neonatal B-Cell Repertoire -- Genetically Programmed Temporal Ordered Activation of Neonatal B-Cell Clones -- Antibody Responses in Fetuses and Newborns -- Effect of Maternal Antibodies on Neonatal B-Cell Response -- Neonatal Autoimmune Diseases Caused by Maternal Pathogenic Autoantibodies -- Phenotypic Characteristics of Neonatal T Cells -- Expression of MHC Molecules in Neonates -- Neonatal Cytokine Network -- Cell-Mediated Immune Responses in Neonates -- Fetal and Neonatal Tolerance -- Development of Efficient Prophylactic Vaccines and Theracines for Newborns and Infants.
520			_aNew advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
650		0	_aMedicine.
650		0	_aImmunology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
700	1		_aBona, Constantin. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588293190
830		0	_aContemporary Immunology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59259-825-0
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502427 _d502427