000			03659nam a22004095i 4500
001			978-1-59259-803-8
003			DE-He213
005			20161121230701.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592598038 _9978-1-59259-803-8
024	7		_a10.1385/159259803X _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
245	1	0	_aMembrane Microdomain Signaling _h[electronic resource] : _bLipid Rafts in Biology and Medicine / _cedited by Mark P. Mattson.
264		1	_aTotowa, NJ : _bHumana Press, _c2005.
300			_aX, 214 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aFrom Intramolecular Asymmetries to Raft Assemblies -- Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells -- Lipid Raft Membrane Skeletons -- Role of Cholesterol in Membrane Microdomain Signaling -- Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis -- The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells -- Role of Rafts in Virus Fusion and Budding -- Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders -- Caveolin and Cancer -- Dietary Modulation of Lipid Rafts.
520			_aLipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts. Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.
650		0	_aLife sciences.
650		0	_aCell biology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
700	1		_aMattson, Mark P. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588293541
856	4	0	_uhttp://dx.doi.org/10.1385/159259803X
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502426 _d502426