000			04093nam a22004455i 4500
001			978-1-59259-785-7
003			DE-He213
005			20161121230701.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592597857 _9978-1-59259-785-7
024	7		_a10.1007/978-1-59259-785-7 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aCancer Gene Therapy _h[electronic resource] / _cedited by David T. Curiel, Joanne T. Douglas.
264		1	_aTotowa, NJ : _bHumana Press, _c2005.
300			_aXII, 490 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Cancer Research
505	0		_aCancer Gene Therapy -- The Genetic Basis of Cancer -- Tumor Suppressor Gene Replacement for Cancer -- Antisense Technology -- Cancer Therapeutic Applications of Ribozymes and RNAi -- Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy -- Suicide Gene Therapy -- Molecular Chemotherapy Approaches -- Genetic Immunotherapy Approaches -- Immunotherapy of Cancer by Dendritic Cell-Targeted Gene Transfer -- Dendritic Cells -- Polynucleotide Immunization for Cancer Therapy -- Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors -- Development of Oncolytic Adenoviruses -- Conditionally Replicating Adenoviruses for Cancer Treatment -- Reovirus as an Oncolytic Agent -- Antiangiogenic Gene Therapy of Cancer -- Proapoptotic Strategy in Cancer Gene Therapy -- Antimetastasis -- Antimetastatic Gene Therapy -- Drug Resistance Gene Transfer as an Antitumor Strategy -- Chemosensitization -- Radiosensitization by Gene Therapy -- Nonviral Vector Systems for Cancer Gene Therapy -- Viral Vectors for Cancer Gene Therapy -- Bacterial Systems for Tumor-Specific Gene Therapy -- Molecular Imaging of Cancer Gene Therapy -- Cancer-Related Gene Therapy Clinical Trials -- Regulatory Aspects in the Development of Gene Therapies.
520			_aToday a new generation of powerful cancer therapeutics targeted against the molecular pathways that produce malignant phenotypes is rapidly emerging. In Cancer Gene Therapy, leading basic and clinical cancer oncologists provide a complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. In their discussions, the authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed. Authoritative and wide ranging, Cancer Gene Therapy offers a comprehensive survey of the molecular basis of cancer gene therapy and demonstrates its enormous potential to take a place in the clinic alongside the current generation of anticancer therapeutics.
650		0	_aMedicine.
650		0	_aCancer research.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
700	1		_aCuriel, David T. _eeditor.
700	1		_aDouglas, Joanne T. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781588292131
830		0	_aContemporary Cancer Research
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-59259-785-7
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502425 _d502425