000 03159nam a22004575i 4500
001 978-1-4020-5132-6
003 DE-He213
005 20161121230700.0
007 cr nn 008mamaa
008 100301s2006 ne | s |||| 0|eng d
020 _a9781402051326
_9978-1-4020-5132-6
024 7 _a10.1007/1-4020-5132-8
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aRegulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs)
_h[electronic resource] :
_bA New Potential Strategy in Cancer Therapy /
_cedited by A-Majid Khatib.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2006.
300 _aX, 157 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aDiscovery of the Proprotein Convertases and their Inhibitors -- Signalling Pathways Leading to Furin Expression in Cancer -- PACE4 Gene Expression in Human Ovarian Cancer -- Proprotein Convertases in Tumorigenesis, Angiogenesis and Metastasis -- Proprotein Convertases, Metalloproteases and Tumor Cell Invasion -- Modulation of Integrin Function by Endoproteolytic Processing: Role in Tumour Progression -- Growth Factors: To Cleave or not to Cleave -- Evaluation of Anti-Proprotein Convertase Activity of Diterpene Andrographolid Derived Products.
520 _aConvertases are widely expressed activating enzymes involved in various physiological and pathological processes. The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting. The book will be of interest to basic researchers as well as clinicians. It will also interest those working in the cancer research area and the pharmaceutical industry, who are looking for new strategies in cancer therapy. Finally, this book is also a useful reference for researchers and clinicians pursuing research on growth factors, adhesion molecules, proteases and their implications in the processes of tumor progression, angiogenesis and metastasis.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aChemistry.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aChemistry/Food Science, general.
700 1 _aKhatib, A-Majid.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402047930
856 4 0 _uhttp://dx.doi.org/10.1007/1-4020-5132-8
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502401
_d502401