000 03192nam a22005655i 4500
001 978-1-4020-5129-6
003 DE-He213
005 20161121230700.0
007 cr nn 008mamaa
008 100301s2006 ne | s |||| 0|eng d
020 _a9781402051296
_9978-1-4020-5129-6
024 7 _a10.1007/978-1-4020-5129-6
_2doi
050 4 _aRD1-811
072 7 _aMN
_2bicssc
072 7 _aMED085000
_2bisacsh
082 0 4 _a617
_223
245 1 0 _aCell Adhesion and Cytoskeletal Molecules in Metastasis
_h[electronic resource] /
_cedited by Anne E. Cress, Raymond B. Nagle.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2006.
300 _aXII, 196 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Metastasis – Biology and Treatment,
_x1568-2102 ;
_v9
505 0 _aCHANGING EXTRACELLULAR MATRIX LIGANDS DURING METASTASIS -- SUPPRESSION AND ALTERATION OF ADHESION STRUCTURES IN HUMAN EPITHELIAL CANCER PROGRESSION -- REGULATION OF CADHERINS DURING PROSTATE CANCER PROGRESSION -- THE ACTIN CYTOSKELETON AND METASTASIS -- CHARACTERIZATION OF THE FERM DOMAIN PROTEIN EHM2 IN HUMAN CANCER CELLS -- CYTOKERATIN 6 EXPRESSION IN PROSTATE STEM CELLS -- EPIGENETIC REGULATION OF GENES THAT AFFECT TUMOR CELL ADHESION -- CELL ADHESION-MEDIATED RADIATION RESISTANCE: THE ROLE OF INTEGRINS AND INTEGRIN PROXIMAL PROTEIN -- CAM-DR: HANGING ON FOR CELL SURVIVAL -- EPITHELIAL CELL SURFACE TARGETING USING SYNTHETIC D-AMINO ACID PEPTIDES.
520 _aIn this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aMolecular biology.
650 0 _aDermatology.
650 0 _aOncology.
650 0 _aPathology.
650 0 _aSurgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aSurgery.
650 2 4 _aCancer Research.
650 2 4 _aMolecular Medicine.
650 2 4 _aDermatology.
650 2 4 _aOncology.
650 2 4 _aPathology.
700 1 _aCress, Anne E.
_eeditor.
700 1 _aNagle, Raymond B.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402051289
830 0 _aCancer Metastasis – Biology and Treatment,
_x1568-2102 ;
_v9
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-5129-6
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502400
_d502400