000			04922nam a22005055i 4500
001			978-1-4020-4142-6
003			DE-He213
005			20161121230658.0
007			cr nn 008mamaa
008			100301s2005 ne | s |||| 0|eng d
020			_a9781402041426 _9978-1-4020-4142-6
024	7		_a10.1007/1-4020-4142-X _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
245	1	0	_aDrug Metabolism _h[electronic resource] : _bCurrent Concepts / _cedited by Corina Ionescu, Mino R. Caira.
264		1	_aDordrecht : _bSpringer Netherlands, _c2005.
300			_aXIV, 422 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aDrug Metabolism In Context: Introduction -- Absorption -- Drug Distribution -- Dynamics Of Drug Action -- Drug Clearance -- Dynamics Of Drug Clearance -- Pathways Of Biotransformation – Phase I Reactions: Introduction -- Phase I And Phase Ii Metabolism: General Considerations -- Oxidations Involving The Microsomal Mixed-Function Oxidase System -- Oxidations Involving Other Enzymatic Systems -- Metabolic Reactions Involving Reduction -- Hydrolysis -- Miscellanous Phase I Reactions -- The Fate Of Phase I Reaction Products -- . Pathways Of Biotransformation – Phase I Reactions: Introduction -- Glucuronidation -- Acetylation -- Glutathione Conjugation -- Other Conjugative Reactions -- Concluding Remarks -- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction -- Interaction Between A Drug Substrate And An Enzyme -- Enzyme Systems With Specific Roles -- Final Remarks -- Induction And Inhibition Of Drug-Metabolising Enzymes -- Introduction -- Induction -- Inhibition -- Consequences Of The Above Phenomena -- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition -- Factors That Influence Drug Biotransformation -- Introduction -- Intrinsic Factors -- Environmental Factors -- Further Observations -- Impact Of Gene Variability On Drug Metabolism -- Introduction -- Basic Principles Of Pharmacogenetics -- Pharmaco-Informatics -- Implications For Third Millennium Medicine -- Drug Interactions And Adverse Reactions: Introduction -- Drug-Drug Interactions -- Interactions Between Drugs And Other Entities -- Adverse Reactions -- Summary -- Strategies For Drug Design -- Introduction -- Pharmacokinetics And Metabolism In Drug Research -- The Role Of Formulation -- Concluding Remarks -- Index.
520			_aDrug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. The book includes chapters on ADME (drug absorption, distribution, metabolism and elimination) Pathways of biotransformation (Phase I and Phase II metabolic reactions) Enzymatic systems involved in biotransformation Induction and inhibition of drug-metabolising enzymes Factors that influence drug biotransformation The role of pharmacogenetics Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
650		0	_aMedicine.
650		0	_aPharmacy.
650		0	_aMolecular biology.
650		0	_aPharmacology.
650		0	_aMedicinal chemistry.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aPharmacy.
650	2	4	_aMedicinal Chemistry.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aMolecular Medicine.
700	1		_aIonescu, Corina. _eeditor.
700	1		_aCaira, Mino R. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402041419
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-4142-X
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502341 _d502341