000			03160nam a22004935i 4500
001			978-1-4020-4009-2
003			DE-He213
005			20161121230658.0
007			cr nn 008mamaa
008			100301s2006 ne | s |||| 0|eng d
020			_a9781402040092 _9978-1-4020-4009-2
024	7		_a10.1007/b103440 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aCell Motility in Cancer Invasion and Metastasis _h[electronic resource] / _cedited by Alan Wells.
264		1	_aDordrecht : _bSpringer Netherlands, _c2006.
300			_aXIII, 353 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v8
505	0		_aMotility in Tumor Invasion and Metastasis — An Overview -- In Vitro Matrices for Studying Tumor Cell Invasion -- Imaging Invasion and Metastasis In Vivo -- Imaging Invasion and Metastasis Ex Vivo -- Autocrine Growth Factor Signaling in Motility -- Scatter Factors in Tumor Progression -- Matrix Metalloproteinases in Tumor Progression -- Dynamic Functions of the ?6?4 Integrin in Carcinoma -- Rho GTpases in Cell Motility and Tumorigenesis -- Glioblastoma Cell Motility: The Role of FAK and Cellular SRC -- Motility in Head and Neck Carcinoma -- Motility in Melanoma Progression -- Cell Motility in Prostate Tumor Invasion and Metastasis.
520			_aCancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aOncology.
650		0	_aLife sciences.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aBiomedicine general.
650	2	4	_aLife Sciences, general.
700	1		_aWells, Alan. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402040085
830		0	_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v8
856	4	0	_uhttp://dx.doi.org/10.1007/b103440
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502333 _d502333