000			03161nam a22005175i 4500
001			978-1-4020-3998-0
003			DE-He213
005			20161121230658.0
007			cr nn 008mamaa
008			100301s2006 ne | s |||| 0|eng d
020			_a9781402039980 _9978-1-4020-3998-0
024	7		_a10.1007/1-4020-3998-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aSchiffer, Davide. _eauthor.
245	1	0	_aBrain Tumor Pathology: Current Diagnostic Hotspots and Pitfalls _h[electronic resource] / _cby Davide Schiffer.
264		1	_aDordrecht : _bSpringer Netherlands, _c2006.
300			_aVI, 272 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe Origin of Gliomas in Relation to the Histological Diagnosis -- Molecular Genetics Outline of Brain Tumors -- General Remarks -- Astrocytic Tumors I -- Astrocytic Tumors II -- Oligodendroglial Tumors -- Ependymal Tumors -- Neuronal and Mixed Glio-Neural Tumors I -- Neuronal and Mixed Glio-Neural Tumors II -- Peculiar Tumors -- Cell Migration and Invasion -- Apoptosis -- The Ubiquitin-Proteasome System -- Angiogenesis -- Meningiomas.
520			_aSince Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aNeurosciences.
650		0	_aNeurology.
650		0	_aNeurosurgery.
650		0	_aPathology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aNeurosciences.
650	2	4	_aPathology.
650	2	4	_aNeurosurgery.
650	2	4	_aNeurology.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402039973
856	4	0	_uhttp://dx.doi.org/10.1007/1-4020-3998-0
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502332 _d502332