000 03350nam a22004935i 4500
001 978-1-4020-3959-1
003 DE-He213
005 20161121230658.0
007 cr nn 008mamaa
008 100301s2006 ne | s |||| 0|eng d
020 _a9781402039591
_9978-1-4020-3959-1
024 7 _a10.1007/1-4020-3959-X
_2doi
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
245 1 0 _aGenetic Engineering of Mesenchymal Stem Cells
_h[electronic resource] /
_cedited by Jan A. Nolta.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2006.
300 _aVI, 170 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aMesenchymal Stem Cell Engineering and Transplantation -- Establishment and Transduction of Primary Human Stromal/Mesenchymal Stem Cell Monolayers -- Gene Expression Profiles of Mesenchymal Stem Cells -- In Vivo Homing and Regeneration of Freshly Isolated and Cultured Murine Mesenchymal Stem Cells -- Non-Human Primate Models of Mesenchymal Stem Cell Transplantation -- Engineering of Human Adipose-Derived Mesenchymal Stem-Like Cells -- Uncommitted Progenitors in Cultures of Bone Marrow-Derived Mesenchymal Stem Cells -- Bone Marrow Mesenchymal Stem Cell Transplantation for Children with Severe Osteogenesis Imperfecta -- Clinical Trials of Human Mesenchymal Stem Cells to Support Hematopoietic Stem Cell Transplantation.
520 _aMSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
650 0 _aLife sciences.
650 0 _aHematology.
650 0 _aSurgical transplantation.
650 0 _aCell biology.
650 0 _aAnimal physiology.
650 1 4 _aLife Sciences.
650 2 4 _aCell Biology.
650 2 4 _aBiomedicine general.
650 2 4 _aHematology.
650 2 4 _aTransplant Surgery.
650 2 4 _aAnimal Physiology.
700 1 _aNolta, Jan A.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402039355
856 4 0 _uhttp://dx.doi.org/10.1007/1-4020-3959-X
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502331
_d502331