000 03041nam a22004935i 4500
001 978-1-4020-3617-0
003 DE-He213
005 20161121230657.0
007 cr nn 008mamaa
008 100301s2005 ne | s |||| 0|eng d
020 _a9781402036170
_9978-1-4020-3617-0
024 7 _a10.1007/978-1-4020-3617-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aFaguet, Guy B.
_eauthor.
245 1 4 _aThe War on Cancer
_h[electronic resource] :
_bAn Anatomy of Failure, A Blueprint for the Future /
_cby Guy B. Faguet.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2005.
300 _aXV, 227 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aCancer Statistics: Some Facts -- Assessing the magnitude of the problem -- The problem is growing, not going away -- What Is Cancer? -- Cancer through the ages -- Our current understanding -- How Is Cancer Treated? -- The cancer cell-kill paradigm and its corollaries -- Chemotherapy drugs -- Treatment outcomes: Dismal by any standard -- Why Does This System Persist? -- The role of the National Cancer Institute -- Publications: The facts and nothing but the facts? -- From the doctors' perspective -- From the patients' perspective -- Where Do We Go From Here? -- A vision for the future -- Shifting from the cell-kill paradigm to pharmacogenomics.
520 _aAfter reviewing the history of cancer and its impact on the population, Dr. Faguet exposes the antiquated notions that have driven cancer drug development, documents the stagnation in treatment outcomes despite major advances in cancer genomics and growing NCI budgets, and identifies the multiple factors that sustain the status quo. He shows that, contrary to frequent announcements of breakthroughs, our current cancer control model cannot eradicate most cancers and the reasons why. Significantly, this book also delineates a way forward via a shift from the discredited cell-kill approach of the past to an integrated, evidence-driven cancer control paradigm based on prevention, early diagnosis, and pharmacogenomics. The author's views are based on data published in mainstream scientific journals and other reliable references, 432 of which are cited.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHuman genetics.
650 0 _aMolecular biology.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aMolecular Medicine.
650 2 4 _aMedicine/Public Health, general.
650 2 4 _aHuman Genetics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402086205
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-3617-0
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502309
_d502309