000			03648nam a22005415i 4500
001			978-1-4020-3270-7
003			DE-He213
005			20161121230656.0
007			cr nn 008mamaa
008			100301s2005 ne | s |||| 0|eng d
020			_a9781402032707 _9978-1-4020-3270-7
024	7		_a10.1007/978-1-4020-3270-7 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
100	1		_aBerke, Gideon. _eauthor.
245	1	0	_aKiller Lymphocytes _h[electronic resource] / _cby Gideon Berke, William R. Clark.
264		1	_aDordrecht : _bSpringer Netherlands, _c2005.
300			_aVIII, 361 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aBasic Immunobiology: A Primer -- Cytotoxic T Lymphocytes: Generation and Cellular Properties -- Cytotoxic T Lymphocytes: Target Cell Recognition and Binding -- Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters -- Cytotoxic T Lymphocytes: Target Cell Killing: Molecular mechanisms -- Innate Cell-mediated Immunity -- The Role of Cytotoxicity in Allograft Rejection In Vivo -- Cytotoxicity in Immune Defenses Against Intracellular Parasites -- Killer Cells and Cancer -- Autoimmunity -- Homeostasis, Memory and CTL Vaccines.
520			_aThe existence of a unique kind of immune cell – the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity – defining the mechanism by which killer cells take down their adversaries – sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aImmunology.
650		0	_aVirology.
650		0	_aHematology.
650		0	_aMicrobiology.
650		0	_aBacteriology.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aCancer Research.
650	2	4	_aVirology.
650	2	4	_aMicrobiology.
650	2	4	_aBacteriology.
650	2	4	_aHematology.
700	1		_aClark, William R. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781402032691
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4020-3270-7
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502290 _d502290