000 04086nam a22004695i 4500
001 978-1-4020-3186-1
003 DE-He213
005 20161121230656.0
007 cr nn 008mamaa
008 100301s2005 ne | s |||| 0|eng d
020 _a9781402031861
_9978-1-4020-3186-1
024 7 _a10.1007/978-1-4020-3186-1
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aSchulz, Wolfgang Arthur.
_eauthor.
245 1 0 _aMolecular Biology of Human Cancers
_h[electronic resource] :
_bAn Advanced Student's Textbook /
_cby Wolfgang Arthur Schulz.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2005.
300 _aXIX, 508 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aMolecules, Mechanisms, And Cells -- An Introduction to Human Cancers -- An Introduction to Human Cancers -- DNA Damage and DNA Repair -- Oncogenes -- Tumor Suppressor Genes -- Cancer Pathways -- Apoptosis and Replicative Senescence in Cancer -- Cancer Epigenetics -- Invasion and metastasis -- Human Cancers -- Leukemias and Lymphomas -- Wilms Tumor (nephroblastoma) -- Cancers of the skin -- Colon Cancer -- Bladder Cancer -- Renal Cell Carcinoma -- Liver Cancer -- Stomach Cancer -- Breast Cancer -- Prostate Cancer -- Prevention, Diagnosis, And Therapy -- Cancer Prevention -- Cancer Diagnosis -- Cancer Therapy.
520 _aOver the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aMolecular biology.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aMolecular Medicine.
650 2 4 _aOncology.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781402031854
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4020-3186-1
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502285
_d502285