000 02899nam a22004575i 4500
001 978-0-387-47257-7
003 DE-He213
005 20161121230655.0
007 cr nn 008mamaa
008 100609s2006 xxu| s |||| 0|eng d
020 _a9780387472577
_9978-0-387-47257-7
024 7 _a10.1007/978-0-387-47257-7
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aSilverman, Scott K.
_eauthor.
245 1 0 _aNucleic Acid Switches and Sensors
_h[electronic resource] /
_cby Scott K. Silverman.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aIX, 125 p. 57 illus., 3 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aArtificial Nucleic Acid Switches and Sensors -- Allosteric Ribozymes as Molecular Switches and Sensors -- Ribozymes and Deoxyribozymes Switched by Oligonucleotides -- Ribozymes Switched by Proteins -- Fluorescence-Signaling Nucleic Acid-Based Sensors -- Natural Nucleic Acid Switches and Sensors -- Protein-Induced RNA Switches in Nature -- Riboswitches as Genetic Control Elements -- Switchable RNA Motifs as Drug Targets.
520 _aIn this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aMedical microbiology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aMedical Microbiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387374918
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-47257-7
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502255
_d502255