000 03870nam a22005055i 4500
001 978-0-387-36673-9
003 DE-He213
005 20161121230654.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387366739
_9978-0-387-36673-9
024 7 _a10.1007/0-387-36673-3
_2doi
050 4 _aQH573-671
072 7 _aPSF
_2bicssc
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aGonzalez-Mariscal, Lorenza.
_eauthor.
245 1 0 _aTight Junctions
_h[electronic resource] /
_cby Lorenza Gonzalez-Mariscal.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXI, 224 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aEvolution of the Transporting Epithelium Phenotype -- Occludin, a Constituent of Tight Junctions -- Tight Junction Channels -- JAM Family Proteins -- Cingulin, a Cytoskeleton-Associated Protein of the Tight Junction -- ZO Proteins and Tight Junction Assembly -- TJ Proteins That Make Round Trips to the Nucleus -- Tight Junctions and the Regulation of Epithelial Cell Proliferation and Gene Expression -- Tight Junction Proteins and Cancer -- Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton -- Regulation of Tight Junctions’ Functional Integrity -- Tight Junctions during Development -- Tight Junctions and the Blood-Brain Barrier -- Tight Junctions in CNS Myelin -- Tight Junction Modulation and Its Relationship to Drug Delivery.
520 _aight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol­ ogy and function in response to physiological, pharmacological and pathologi­ cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec­ tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand­ ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.
650 0 _aLife sciences.
650 0 _aCancer research.
650 0 _aNeurosciences.
650 0 _aPharmacology.
650 0 _aCell biology.
650 0 _aNeurobiology.
650 1 4 _aLife Sciences.
650 2 4 _aCell Biology.
650 2 4 _aNeurosciences.
650 2 4 _aNeurobiology.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387332017
856 4 0 _uhttp://dx.doi.org/10.1007/0-387-36673-3
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502240
_d502240