000 03819nam a22004815i 4500
001 978-0-387-34132-3
003 DE-He213
005 20161121230653.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387341323
_9978-0-387-34132-3
024 7 _a10.1007/0-387-34132-3
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aLymphocyte Signal Transduction
_h[electronic resource] /
_cedited by Constantine Tsoukas.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXVII, 302 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v584
505 0 _aProtein Kinase C-Theta (PKC?): New Perspectives on Its Functions in T Cell Biology -- Travel Informations on the TEC Kinases during Lymphocyte Activation -- Inducible T Cell Tyrosine Kinase (ITK): Structural Requirements and Actin Polymerization -- Differential Requirements of PI3K Subunits for BCR or BCR/CD19-Induced ERK Activation -- Protein Tyrosine Phosphatases in Human Disease -- The T Cell-Specific Adapter Protein Functions as a Regulator of Peripheral but not Central Immunological Tolerance -- Proximal Signals Controlling B-Cell Antigen Receptor (BCR) Mediated NF-?B Activation -- The Adapter 3BP2: How It Plugs into Leukocyte Signaling -- CTLA-4 Regulation of T Cell Function via RAP-1-Mediated Adhesion -- Protein Crosstalk in Lipid Rafts -- Role of Lipid Rafts in Activation-Induced Cell Death : The Fas Pathway in Aging -- T Cell Response in Aging: Influence of Cellular Cholesterol Modulation -- Lymphocyte Signaling and the Translatability of mRNA -- Protein Arginine Methylation: A New Frontier in T Cell Signal Transduction -- Immune Regulation by Ubiquitin Conjugation -- CTIB (C-Terminus Protein of I?B-?: A Novel Factor Required for Acidic Adaptation -- HIV May Deplete Most CD4 Lymphocytes by a Mechanism Involving Signaling through its Receptors on Non-Permissive Resting Lymphocytes -- Integrating Traditional and Postgenomic Approaches to Investigate Lymphocyte Development and Function -- Phosphoproteomic Analysis of Lymphocyte Signaling.
520 _aSignal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated by inter- and intra-molecular interactions, as well as by various post-translational modifications, lead to the activation of transcription factors that mediate cellular differentiation and growth, effector cell functions, and apoptotic cell death. Several investigators from various parts of the world convened at the 3rd Lymphocyte Signal Transduction Workshop in Crete, Greece from May 27 to June 1, 2005 to discuss their most recent findings in leukocyte signaling. This volume represents a collection of topics discussed during the conference.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aInfectious diseases.
650 0 _aMicrobiology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aMicrobiology.
650 2 4 _aInfectious Diseases.
700 1 _aTsoukas, Constantine.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387313351
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v584
856 4 0 _uhttp://dx.doi.org/10.1007/0-387-34132-3
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502227
_d502227