000 04238nam a22005175i 4500
001 978-0-387-31047-3
003 DE-He213
005 20161121230652.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387310473
_9978-0-387-31047-3
024 7 _a10.1007/978-0-387-31047-3
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
245 1 0 _aNew Concepts of Antiviral Therapy
_h[electronic resource] /
_cedited by Andreas Holzenburg, Elke Bogner.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXX, 538 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aConcepts of therapy for RNA viruses -- Therapeutic vaccination in chronic hepadnavirus infection -- Characterization of targets for antiviral therapy of Flaviviridae infections -- Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches -- Inhibitors of respiratory viruses -- Anti-viral approaches against influenza viruses -- A new approach to an Influenza virus live vaccine: Modification of eleavage site of the haemagglu reverse genetics -- New concepts in anti-HIV therapies -- Evaluation of current strategies to inhibit HIV entry, integration and maturation -- Managing antiretroviral resistance -- Concepts of therapy for DNA viruses -- Selective inhibitors of the replication of poxviruses -- Maribavir: A promising new antiherpes therapeutic agent -- Benzimidazole-D-ribonucleosides as antiviral agents that target HCMV terminase -- Recent developments in anti-herpesviral therapy based on protein kinase inhibitors -- Immune therapy against papillomavirus-related tumors in humans -- Concepts of therapy for emerging viruses -- The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapy -- Therapy of Ebola and Marburg virus infections -- General concepts of therapy -- Proteasome inhibitors as complementary or alternative antiviral therapeutics -- Human monoclonal antibodies for prophylaxis and therapy of viral infections -- Vector-based antiviral therapy.
520 _aAntiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of: - novel, promising compounds - concepts of therapy for new/emerging viruses - managing drug resistance - new therapeutic strategies This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.
650 0 _aMedicine.
650 0 _aMedical microbiology.
650 0 _aPharmacology.
650 0 _aVirology.
650 0 _aMedical biochemistry.
650 0 _aMicrobiology.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aMedical Microbiology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMicrobiology.
650 2 4 _aMedical Biochemistry.
700 1 _aHolzenburg, Andreas.
_eeditor.
700 1 _aBogner, Elke.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387310466
856 4 0 _uhttp://dx.doi.org/10.1007/978-0-387-31047-3
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502184
_d502184