000			03523nam a22005295i 4500
001			978-0-387-23923-1
003			DE-He213
005			20161121230648.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387239231 _9978-0-387-23923-1
024	7		_a10.1007/b103635 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
245	1	0	_aNeurodegeneration and Prion Disease _h[electronic resource] / _cedited by David R. Brown.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXV, 473 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aNeuropathology of Transmissible Spongiform Encephalopathies (Prion Diseases) -- Central Pathogenesis of Prion Diseases -- Hereditary Prion Protein Amyloidoses -- Mouse Behavioural Studies and What They Can Teach Us about Prion Diseases -- Electrophysiological Approaches to the Study of Prion Diseases -- Prion Protein, Prion Protein-Like Protein, and Neurodegeneration -- Oxidative Stress and Mitochondrial Dysfunction in Neurodegeneration of Transmissible Spongiform Encephalopathies (TSEs) -- Mechanisms of Prion Toxicity and Their Relationship to Prion Infectivity -- A Stone Guest on the Brain: Death as a Prion -- Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro -- Processing and Mis-Processing of the Prion Protein: Insights into the Pathogenesis of Familial Prion Disorders -- Signaling Pathways Controling Prion Neurotoxicity: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis -- Cell Culture Models to Unravel Prion Protein Function and Aberrancies in TSE -- Insights into the Cellular Trafficking of Prion Proteins -- The Molecular Basis of Prion Protein-Mediated Neuronal Damage -- Conclusion: Intervention, the Final Frontier.
520			_aThis volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow’s disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
650		0	_aMedicine.
650		0	_aMolecular biology.
650		0	_aNeurosciences.
650		0	_aNeurology.
650		0	_aVeterinary medicine.
650		0	_aBiochemistry.
650		0	_aBiomathematics.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aPhysiological, Cellular and Medical Topics.
650	2	4	_aNeurology.
650	2	4	_aBiochemistry, general.
650	2	4	_aVeterinary Medicine.
650	2	4	_aMolecular Medicine.
700	1		_aBrown, David R. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387239224
856	4	0	_uhttp://dx.doi.org/10.1007/b103635
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502082 _d502082