000 03648nam a22005175i 4500
001 978-0-387-23695-7
003 DE-He213
005 20161121230647.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387236957
_9978-0-387-23695-7
024 7 _a10.1007/b102187
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
245 1 0 _aApoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases
_h[electronic resource] /
_cedited by Marek Los, Spencer B. Gibson.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXXVI, 395 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aApoptotic Pathways and Their Regulation -- Mechanisms of Anticancer Drug Action -- Death Receptor Pathways As Targets for Anticancer Therapy -- Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies -- The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: Bcl-2 Family in Focus -- Survivin, other IAPs, Smac/Diablo, and Omi/Htra2 — Modulation of the Advancing Apoptotic Process -- The Life Cycle of P53: A Key Target in Drug Development -- Growth Factors, Receptors, and Kinases: Their Exploration to Target Cancer -- Targets for Apoptotic Intervention in Rheumatoid Arthritis -- Therapeutic Inhibition of Apoptosis Caused by Stroke -- Monoclonal and Bispecific Antibodies as Novel Therapeutics -- Targeting the Proteasome in Cancer Therapy -- D-RNAi-Based Therapeutics -- Nuclear Transcription Factor-?B: A Drug Target for all Seasons -- Monitoring of Programmed cell Death in Vivo and in Vitro,—New and Old Methods of Cancer Therapy Assessment -- Current Strategies in Tumor-Targeting -- Strategies of Protection of Normal Cells During Chemo- and Radio-Therapy Based on Modulation of Cell Cycle and Apoptotic Pathways.
520 _aAs our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHuman genetics.
650 0 _aImmunology.
650 0 _aPharmacology.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
650 2 4 _aImmunology.
650 2 4 _aHuman Genetics.
700 1 _aLos, Marek.
_eeditor.
700 1 _aGibson, Spencer B.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387233840
856 4 0 _uhttp://dx.doi.org/10.1007/b102187
912 _aZDB-2-SBL
950 _aBiomedical and Life Sciences (Springer-11642)
999 _c502078
_d502078