000			03779nam a22005295i 4500
001			978-0-387-23250-8
003			DE-He213
005			20161121230647.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387232508 _9978-0-387-23250-8
024	7		_a10.1007/b101086 _2doi
050		4	_aQR180-189.5
072		7	_aMJCM _2bicssc
072		7	_aMED044000 _2bisacsh
082	0	4	_a616.079 _223
245	1	0	_aDefects of Secretion in Cystic Fibrosis _h[electronic resource] / _cedited by Carsten Schultz.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXIV, 179 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v558
505	0		_aOutside Neurons/Inside Epithelia: Novel Activation of CFTR Cl? and HCO3 ? Conductances -- Role of CFTR and Other Ion Channels in Cystic Fibrosis -- Ion Channels in the Apical Membrane: Role of Electrical Coupling on Transepithelial Transport -- Ion Channels in Secretory Granules of the Pancreas: Molecular Identification and Their Role in Regulated Secretion -- Epithelial Transport and Intracellular Trafficking: Physiology and Pathophysiology -- Kinases, Cell Volume, and the Regulation of Chloride Channels -- The CLCAs: Proteins with Ion Channel, Cell Adhesion and Tumor Suppressor Functions -- Is Intervention in Inositol Phosphate Signaling a Useful Therapeutic Option for Cystic Fibrosis? -- An Inositol Phosphate Analog, INO-4995, Normalizes Electrophysiology in CF Airway Epithelia -- Vitamin C and Flavonoids Potentiate CFTR Cl Transport in Human Airway Epithelia -- Airway Glycoconjugates Secreted in Cystic Fibrosis and Severe Chronic Airway Inflammation Relationship with Pseudomonas aeruginosa -- Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic Fibrosis.
520			_aDefects in Secretion of Cystic Fibrosis presents an overview on current research from leading experts in North America and Europe. This update on cystic fibrosis provides in depth original work as well as review material on many of the relevant physiological and molecular topics in the field. Subjects covered include the interplay of the various epithelial ion channels, the underlying intracellular signal transduction, mucus secretion, and novel approaches to develop drugs against cystic fibrosis. This book brings together physicians, physiologists, and other scientists involved in basic research, from molecular biology to drug design and introduces novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and related diseases. This book will be of interest to Molecular biologists, physiologists, scientists working in pharmaceutical research and drug developement, physicians and researchers in Cystic fibrosis and related diseases.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aMedical microbiology.
650		0	_aMolecular biology.
650		0	_aPharmacology.
650		0	_aInternal medicine.
650	1	4	_aBiomedicine.
650	2	4	_aImmunology.
650	2	4	_aMedical Microbiology.
650	2	4	_aMolecular Medicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aInternal Medicine.
700	1		_aSchultz, Carsten. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387230764
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v558
856	4	0	_uhttp://dx.doi.org/10.1007/b101086
912			_aZDB-2-SBL
950			_aBiomedical and Life Sciences (Springer-11642)
999			_c502070 _d502070