000 04598nam a22006015i 4500
001 978-3-540-35662-2
003 DE-He213
005 20161121230644.0
007 cr nn 008mamaa
008 100301s2006 gw | s |||| 0|eng d
020 _a9783540356622
_9978-3-540-35662-2
024 7 _a10.1007/3-540-35662-2
_2doi
050 4 _aR895-920
072 7 _aMMPH
_2bicssc
072 7 _aMMP
_2bicssc
072 7 _aMED008000
_2bisacsh
082 0 4 _a616.0757
_223
245 1 0 _aMultimodal Concepts for Integration of Cytotoxic Drugs
_h[electronic resource] /
_cedited by J. Martin Brown, Minesh P. Mehta, Carsten Nieder.
246 3 _aWith contributions by numerous experts
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2006.
300 _aX, 352 p. 14 illus., 12 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMedical Radiology, Radiation Oncology,
_x0942-5373
505 0 _aPreclinical Part -- Biological Basis of Combined Radio- and Chemotherapy -- Combinations of Antimetabolites and Ionizing Radiation -- Combinations of Taxanes and Ionizing Radiation -- Combinations of Topoisomerase Inhibitors and Ionizing Radiation -- Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation -- Combinations of Platinum Compounds and Ionizing Radiation -- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors -- Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors -- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors -- Combinations of Ionizing Radiation and Other Sensitizing Agents -- Radiotherapy and Tumor-Targeted Drug Delivery -- Clinical Part -- Applications in Malignant Brain Tumors -- Applications in Head and Neck Cancer -- Applications in Esophageal and Gastric Cancer -- Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies -- Applications in Lung Cancer -- Integration of Radiation Therapy and Systemic Therapy for Breast Cancer -- Applications in Rectal and Anal Cancer -- Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer -- Applications to Gynecological Cancers -- Early and Late Treatment-Induced Toxicity -- Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients.
520 _aOver recent decades, combined modality treatment has drastically improved the cure rates for various malignant tumors. Further progress is expected through the design of sound combinations involving recently developed drugs. The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed. All of the chapters have been written by basic scientists and clinicians who are acknowledged experts in the field. The text is specifically designed to be accessible to professionals from the various disciplines involved in multidisciplinary cancer care and to residents in radiation oncology training programs.
650 0 _aMedicine.
650 0 _aRadiology.
650 0 _aRadiotherapy.
650 0 _aRespiratory organs
_xDiseases.
650 0 _aOncology.
650 0 _aMedical biochemistry.
650 0 _aSurgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aImaging / Radiology.
650 2 4 _aRadiotherapy.
650 2 4 _aOncology.
650 2 4 _aMedical Biochemistry.
650 2 4 _aSurgery.
650 2 4 _aPneumology/Respiratory System.
700 1 _aBrown, J. Martin.
_eeditor.
700 1 _aMehta, Minesh P.
_eeditor.
700 1 _aNieder, Carsten.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783540256557
830 0 _aMedical Radiology, Radiation Oncology,
_x0942-5373
856 4 0 _uhttp://dx.doi.org/10.1007/3-540-35662-2
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c501999
_d501999