000 04157nam a22004575i 4500
001 978-0-387-29553-4
003 DE-He213
005 20161121230635.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387295534
_9978-0-387-29553-4
024 7 _a10.1007/0-387-29553-4
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
245 1 0 _aAntioxidants and Cardiovascular Disease
_h[electronic resource] /
_cedited by Martial G. Bourassa, Jean-Claude Tardif.
250 _aSecond Edition.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXVI, 494 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aDevelopments in Cardiovascular Medicine,
_x0166-9842 ;
_v258
505 0 _aGeneral Concepts about Oxidative Stress -- Lipoproteins and Oxidation -- Pathogenesis of Atherosclerosis -- The Antioxidant Hypothesis -- Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Diseases -- Biomarkers of Oxidant Stress in Vivo: Oxidative Modifications of Lipids, Proteins and DNA -- Pharmacological Compounds with Antioxidant Activity -- Antioxidant Nutrients and Antioxidant Nutrient-Rich Foods Against Coronary Heart Disease -- Antioxidants and Chronic Vascular Disease: Animal Studies -- Synthetic Antioxidants and Atherosclerosis: Human Studies -- Antioxidants and Endothelial Function: Human Studies -- Antioxidant Vitamins and Cardiovascular Disease: Randomized Trials Fail to Fulfill the Promises of Observational Epidemiology -- Antioxidants and Restenosis after Percutaneous Coronary Intervention: Animal Studies -- Antioxidants and Restenosis after Percutaneous Coronary Intervention: Human Studies -- Oxidative Stress in Hypertension -- Oxidative Stress in the Development of Diabetes and its Complications -- Anti-Inflammatory and Antioxidant Functions of High Density Lipoproteins -- Oxidative Stress in Heart Failure -- Use of Antioxidants in Patients with Congestive Heart Failure.
520 _aAntioxidants and Cardiovascular Disease, Second Edition addresses a complex but very timely and fascinating problem in cardiovascular medicine. It is written by recognized experts in the fields of atherosclerosis and antioxidants. It should be of interest not only to academicians but also to practicing physicians. The first five chapters review the general concepts of oxidative stress and their relationship to lipid metabolism, endothelial dysfunction, genetics and transcriptional factors. The next seven chapters describe recently defined markers of oxidative stress, pharmacological compounds with antioxidant activity, natural antioxidants found in micronutrients and in nutrient-rich diets, and reviews the recent evidence for their efficacy or lack of efficacy in patients with cardiovascular disease or cardiovascular risk factors. The last seven chapters discuss the potential therapeutic benefits of antioxidants in a number of cardiovascular conditions which include atherosclerosis, restenosis after percutaneous coronary intervention, major cardiovascular risk factors such as hypertension, diabetes mellitus and dyslipidemia, and left ventricular dysfunction and congestive heart failure. Martial G. Bourassa, M.D. and Jean-Claude Tardif, M.D. are affiliated with the Montreal Heart Institute, Research Center and Department of Medicine, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
650 0 _aMedicine.
650 0 _aCardiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
700 1 _aBourassa, Martial G.
_eeditor.
700 1 _aTardif, Jean-Claude.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387295527
830 0 _aDevelopments in Cardiovascular Medicine,
_x0166-9842 ;
_v258
856 4 0 _uhttp://dx.doi.org/10.1007/0-387-29553-4
912 _aZDB-2-SME
950 _aMedicine (Springer-11650)
999 _c501754
_d501754